Cancer genetics, genetic counseling, and cancer control

The authors studied a kindred among whom adenocarcinoma of the colon and endometrium and multiple primary malignant neoplasms have occurred with increased frequency through three generations. These findings fulfill the criteria for the cancer family syndrome which includes: increased frequency of adenocarcinoma, particularly of colon and endometrium; increased frequency of multiple primary malignant neoplasms; early age of onset of cancer, when compared to expectations from the general population; and vertical transmission of cancer consistent with autosomal dominant mode of genetic transmission.