Cancer of the esophagus: A model of causation

John S. Neuberger; Henry T. Lynch

doi:10.1016/0306-9877(82)90164-5

Cancer of the esophagus: A model of causation

John S. Neuberger, Henry T. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.

Original language	English (US)
Pages (from-to)	337-342
Number of pages	6
Journal	Medical Hypotheses
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0306-9877(82)90164-5
State	Published - Sep 1982

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/0306-9877(82)90164-5

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title = "Cancer of the esophagus: A model of causation",

abstract = "Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.",

author = "Neuberger, {John S.} and Lynch, {Henry T.}",

note = "Funding Information: This project was supported in part by the Mid America Cancer Center at the University of Kansas School of Medicine, the American Cancer Society (Grant No. IN115), the U.S. Environmental Protection Agency, Region VII (Contract No. K0575 NTEX), and the Council for Tobacco Research, USA, Inc., (Grant No. 1297M). Thomas J. Mason, Ph.D., Head, Population Studies Section, Environmental Epidemiology Branch, National Cancer Institute, provided mortality data for 1950-1969 and population data for 1970-1975. Nebraska mortality data for 1968-1977 was provided by Mary L. Eastman, Director, Division of Health Data and Statistical Research, Department of Health, State of Nebraska.",

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AB - Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.

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Cancer of the esophagus: A model of causation

Abstract

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