Abstract
Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.
| Original language | English |
|---|---|
| Pages (from-to) | 337-342 |
| Number of pages | 6 |
| Journal | Medical Hypotheses |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1982 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Medicine(all)
- Drug Discovery
Cite this
Cancer of the esophagus : A model of causation. / Neuberger, John S.; Lynch, Henry T.
In: Medical Hypotheses, Vol. 9, No. 3, 1982, p. 337-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer of the esophagus
T2 - A model of causation
AU - Neuberger, John S.
AU - Lynch, Henry T.
PY - 1982
Y1 - 1982
N2 - Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.
AB - Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019971914&partnerID=8YFLogxK
U2 - 10.1016/0306-9877(82)90164-5
DO - 10.1016/0306-9877(82)90164-5
M3 - Article
C2 - 7144639
AN - SCOPUS:0019971914
VL - 9
SP - 337
EP - 342
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 3
ER -