Cardiac Complications of COVID-19 Infection and the Role of Physical Activity

Aiman Smer, Ray W. Squires, Amanda R. Bonikowske, Thomas G. Allison, Rylie N. Mainville, Mark A. Williams

Research output: Contribution to journalReview articlepeer-review


Since December 2019, the newly emerging coronavirus has become a global pandemic with >250 million people infected and >5 million deaths worldwide. Infection with coronavirus disease-2019 (COVID-19) causes a severe immune response and hypercoagulable state leading to tissue injury, organ damage, and thrombotic events. It is well known that COVID-19 infection predominately affects the lungs; however, the cardiovascular complications of the disease have been a major cause of morbidity and mortality. In addition, patients with cardiovascular disease are vulnerable to contract a severe form of the illness and increased mortality. A significant number of patients who survived the disease may experience post-COVID-19 syndrome with a variety of symptoms and physical limitations. Here, we review the cardiac complications of COVID-19 infection and the results of cardiopulmonary exercise testing and guidelines for exercise training after infection.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Issue number1
StatePublished - Jan 1 2023

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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