CD4+CD25- effector T-cells inhibit hippocampal long-term potentiation in vitro

Gil M. Lewitus, Julia Zhu, Huangui Xiong, Richard J. Hallworth, Jonathan Kipnis

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Abstract

During neuroinflammation T-cells invade the CNS, and may lead to the development and progression of several pathologies, of which multiple sclerosis is the most common. In these pathologies neuroinflammation is often associated with cognitive dysfunction. Using mouse hippocampal slices, we show here that CD4+CD25- T-cells inhibit long-term potentiation (LTP) induced by high-frequency stimulation. The T-cell-mediated inhibition of LTP can be prevented by blockade of γ-aminobutyric acid (GABA)A receptors. These findings provide additional insight into the multiple functions of T-cells in CNS pathologies.

Original languageEnglish
Pages (from-to)1399-1406
Number of pages8
JournalEuropean Journal of Neuroscience
Volume26
Issue number6
DOIs
Publication statusPublished - Sep 2007

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CD4+CD25- effector T-cells inhibit hippocampal long-term potentiation in vitro. / Lewitus, Gil M.; Zhu, Julia; Xiong, Huangui; Hallworth, Richard J.; Kipnis, Jonathan.

In: European Journal of Neuroscience, Vol. 26, No. 6, 09.2007, p. 1399-1406.

Research output: Contribution to journalArticle