Celecoxib treatment alters the gene expression profile of normal colonic mucosa

Oleg K. Glebov, Luz M. Rodriguez, Patrick Lynch, Sherri Patterson, Henry Lynch, Kenneth Nakahara, Jean Jenkins, Janet Cliatt, Casey Jo Humbyrd, John DeNobile, Peter Soballe, Steven Gallinger, Aby Buchbinder, Gary Gordon, Ernest Hawk, Ilan R. Kirsch

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23 Scopus citations

Abstract

A clinical trial was recently conducted to evaluate the safety and efficacy of a selective inhibitor of cyclooxygenase-2 (celecoxib) in hereditary nonpolyposis colon cancer patients. In a randomized, placebo-controlled phase I/II multicenter trial, hereditary nonpolyposis colon cancer patients and gene carriers received either celecoxib at one of two doses or placebo. The goal was to evaluate the effects of these treatment arms on a number of endoscopic and tissue-based biomarker end points after 12 months of treatment. As part of this trial, we analyzed gene expression by cDNA array technology in normal descending (rectal) colonic mucosa of patients before and after treatment with celecoxib or placebo. We found that treatment of patients with celecoxib at recommended clinical doses (200 and 400 mg p.o. bid), in contrast to treatment with placebo, leads to changes in expression of >1,400 genes in the healthy colon, although in general, the magnitude of changes is

Original languageEnglish (US)
Pages (from-to)1382-1391
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2006

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

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    Glebov, O. K., Rodriguez, L. M., Lynch, P., Patterson, S., Lynch, H., Nakahara, K., Jenkins, J., Cliatt, J., Humbyrd, C. J., DeNobile, J., Soballe, P., Gallinger, S., Buchbinder, A., Gordon, G., Hawk, E., & Kirsch, I. R. (2006). Celecoxib treatment alters the gene expression profile of normal colonic mucosa. Cancer Epidemiology Biomarkers and Prevention, 15(7), 1382-1391. https://doi.org/10.1158/1055-9965.EPI-04-0866