Cell Competition during Growth and Regeneration

Rajan Gogna, Kevin Shee, Eduardo Moreno

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations

    Abstract

    Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which stem cells within the organ self-renew and differentiate to create new cells, leading to new tissue. The processes of growth and regeneration require communication and interplay between neighboring cells. In particular, cell competition, which is a process in which viable cells are actively eliminated by more competitive cells, has been increasingly implicated to play an important role. Here, we discuss the existing literature regarding the current landscape of cell competition, including classical pathways and models, fitness fingerprint mechanisms, and immune system mechanisms of cell competition. We further discuss the clinical relevance of cell competition in the physiological processes of tissue growth and regeneration, highlighting studies in clinically important disease models, including oncological, neurological, and cardiovascular diseases.

    Original languageEnglish (US)
    Pages (from-to)697-718
    Number of pages22
    JournalAnnual Review of Genetics
    Volume49
    DOIs
    StatePublished - Nov 23 2015

    All Science Journal Classification (ASJC) codes

    • Genetics

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