TY - JOUR
T1 - Cell Competition during Growth and Regeneration
AU - Gogna, Rajan
AU - Shee, Kevin
AU - Moreno, Eduardo
N1 - Publisher Copyright:
Copyright © 2015 by Annual Reviews. All rights reserved.
PY - 2015/11/23
Y1 - 2015/11/23
N2 - Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which stem cells within the organ self-renew and differentiate to create new cells, leading to new tissue. The processes of growth and regeneration require communication and interplay between neighboring cells. In particular, cell competition, which is a process in which viable cells are actively eliminated by more competitive cells, has been increasingly implicated to play an important role. Here, we discuss the existing literature regarding the current landscape of cell competition, including classical pathways and models, fitness fingerprint mechanisms, and immune system mechanisms of cell competition. We further discuss the clinical relevance of cell competition in the physiological processes of tissue growth and regeneration, highlighting studies in clinically important disease models, including oncological, neurological, and cardiovascular diseases.
AB - Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which stem cells within the organ self-renew and differentiate to create new cells, leading to new tissue. The processes of growth and regeneration require communication and interplay between neighboring cells. In particular, cell competition, which is a process in which viable cells are actively eliminated by more competitive cells, has been increasingly implicated to play an important role. Here, we discuss the existing literature regarding the current landscape of cell competition, including classical pathways and models, fitness fingerprint mechanisms, and immune system mechanisms of cell competition. We further discuss the clinical relevance of cell competition in the physiological processes of tissue growth and regeneration, highlighting studies in clinically important disease models, including oncological, neurological, and cardiovascular diseases.
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U2 - 10.1146/annurev-genet-112414-055214
DO - 10.1146/annurev-genet-112414-055214
M3 - Article
C2 - 26631518
AN - SCOPUS:84948776760
VL - 49
SP - 697
EP - 718
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -