TY - JOUR
T1 - Cell-free fetal DNA in maternal plasma
T2 - Progress and potential
AU - Smith, James F.
AU - Blumenfeld, Yair
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.
AB - Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.
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U2 - 10.1542/neo.9-8-e332
DO - 10.1542/neo.9-8-e332
M3 - Article
AN - SCOPUS:56549098101
VL - 9
SP - e332-e336
JO - NeoReviews
JF - NeoReviews
SN - 1526-9906
IS - 8
ER -