Cell-free fetal DNA in maternal plasma: Progress and potential

James F. Smith, Yair Blumenfeld

Research output: Contribution to journalArticlepeer-review


Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.

Original languageEnglish (US)
Pages (from-to)e332-e336
Issue number8
StatePublished - Aug 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Cell-free fetal DNA in maternal plasma: Progress and potential'. Together they form a unique fingerprint.

Cite this