Cell-free fetal DNA in maternal plasma: Progress and potential

James Smith, Jr., Yair Blumenfeld

Research output: Contribution to journalArticle

Abstract

Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.

Original languageEnglish
JournalNeoReviews
Volume9
Issue number8
DOIs
StatePublished - Aug 2008

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Mothers
DNA
Aneuploidy
Prenatal Diagnosis
Research
Fetus
Genome

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Cell-free fetal DNA in maternal plasma : Progress and potential. / Smith, Jr., James; Blumenfeld, Yair.

In: NeoReviews, Vol. 9, No. 8, 08.2008.

Research output: Contribution to journalArticle

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