Abstract
Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.
| Original language | English |
|---|---|
| Journal | NeoReviews |
| Volume | 9 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2008 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
Cite this
Cell-free fetal DNA in maternal plasma : Progress and potential. / Smith, Jr., James; Blumenfeld, Yair.
In: NeoReviews, Vol. 9, No. 8, 08.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell-free fetal DNA in maternal plasma
T2 - Progress and potential
AU - Smith, Jr., James
AU - Blumenfeld, Yair
PY - 2008/8
Y1 - 2008/8
N2 - Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.
AB - Since the discovery of cell-free fetal (cffDNA) in peripheral maternal blood a decade ago, advances have been made in the identification and clinical application of these segments. Most studies of cffDNA have focused on using the segments for sex determination and fetal Rh genotyping, employing differnces in genome DNA between mother and fetus. Research has shifted toward targeting cffDNA for noninvasive aneuploidy detection. Over the last decade, a tremendous volume of research has focused on advancing the understanding of cffDNA structure, function, and detection. Despite this growing body of evidence, gaps in understanding of the biology of cffDNA and challenges in its isolation, enrichment, and processing have limited clinical applications in noninvasive prenatal diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=56549098101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56549098101&partnerID=8YFLogxK
U2 - 10.1542/neo.9-8-e332
DO - 10.1542/neo.9-8-e332
M3 - Article
AN - SCOPUS:56549098101
VL - 9
JO - NeoReviews
JF - NeoReviews
SN - 1526-9906
IS - 8
ER -