Abstract
Atherosclerosis and restenosis are the result of vascular injury followed by an inflammatory and fibroproliferative response that involves a large number of growth factors, cytokines, and cellular elements. Platelet activation and leukocyte recruitment into the arterial intima play a crucial role, initiating a whole spectrum of reactions leading to vascular smooth muscle cell hyperplasia and intimal migration. The roles of macrophages and lymphocytes and mast cells as mediators of inflammation and immune response is discussed, as are the roles of growth factors and cytokines. New light on the Old' problems will help us to devise newer and better therapeutic strategies to combat these clinical entities.
| Original language | English |
|---|---|
| Pages (from-to) | 701-715 |
| Number of pages | 15 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Volume | 83 |
| Issue number | 8-9 |
| DOIs | |
| State | Published - Aug 2005 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
Cite this
Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies. / Mitra, Amit K.; Del Core, Michael; Agrawal, Devendra K.
In: Canadian Journal of Physiology and Pharmacology, Vol. 83, No. 8-9, 08.2005, p. 701-715.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies
AU - Mitra, Amit K.
AU - Del Core, Michael
AU - Agrawal, Devendra K.
PY - 2005/8
Y1 - 2005/8
N2 - Atherosclerosis and restenosis are the result of vascular injury followed by an inflammatory and fibroproliferative response that involves a large number of growth factors, cytokines, and cellular elements. Platelet activation and leukocyte recruitment into the arterial intima play a crucial role, initiating a whole spectrum of reactions leading to vascular smooth muscle cell hyperplasia and intimal migration. The roles of macrophages and lymphocytes and mast cells as mediators of inflammation and immune response is discussed, as are the roles of growth factors and cytokines. New light on the Old' problems will help us to devise newer and better therapeutic strategies to combat these clinical entities.
AB - Atherosclerosis and restenosis are the result of vascular injury followed by an inflammatory and fibroproliferative response that involves a large number of growth factors, cytokines, and cellular elements. Platelet activation and leukocyte recruitment into the arterial intima play a crucial role, initiating a whole spectrum of reactions leading to vascular smooth muscle cell hyperplasia and intimal migration. The roles of macrophages and lymphocytes and mast cells as mediators of inflammation and immune response is discussed, as are the roles of growth factors and cytokines. New light on the Old' problems will help us to devise newer and better therapeutic strategies to combat these clinical entities.
UR - http://www.scopus.com/inward/record.url?scp=28944446725&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28944446725&partnerID=8YFLogxK
U2 - 10.1139/y05-080
DO - 10.1139/y05-080
M3 - Review article
C2 - 16333372
AN - SCOPUS:28944446725
VL - 83
SP - 701
EP - 715
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
SN - 0008-4212
IS - 8-9
ER -