Abstract
Although the incidence of lung cancer is declining, the prognosis remains poor. This is likely due to lack of early detection and only recent developments in selective cancer therapies. Key immune cells involved in the pathogenesis of lung cancer include CD4+ T lymphocytes, macrophages, dendritic cells and NK cells. The growing understanding of these cells indicates a highly complex and intertwined network of their involvement in each stage of lung cancer. Immune cell types and numbers affect prognosis and could offer an opportunity for clinical therapeutic applications. However, an incomplete understanding of immune cell involvement and the underlying processes in lung cancer still remain. Deeper investigation focusing on the role of the immune cells will further the understanding of lung carcinogenesis and develop novel therapeutic approaches for the treatment and management of patients with more specialized and selective lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1711-1730 |
| Number of pages | 20 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2014 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Medicine(all)
Cite this
Cellular and molecular immunology of lung cancer : Therapeutic implications. / Nguyen, Austin Huy; Berim, Ilya; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 10, No. 12, 01.12.2014, p. 1711-1730.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cellular and molecular immunology of lung cancer
T2 - Therapeutic implications
AU - Nguyen, Austin Huy
AU - Berim, Ilya
AU - Agrawal, Devendra K.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Although the incidence of lung cancer is declining, the prognosis remains poor. This is likely due to lack of early detection and only recent developments in selective cancer therapies. Key immune cells involved in the pathogenesis of lung cancer include CD4+ T lymphocytes, macrophages, dendritic cells and NK cells. The growing understanding of these cells indicates a highly complex and intertwined network of their involvement in each stage of lung cancer. Immune cell types and numbers affect prognosis and could offer an opportunity for clinical therapeutic applications. However, an incomplete understanding of immune cell involvement and the underlying processes in lung cancer still remain. Deeper investigation focusing on the role of the immune cells will further the understanding of lung carcinogenesis and develop novel therapeutic approaches for the treatment and management of patients with more specialized and selective lung cancer.
AB - Although the incidence of lung cancer is declining, the prognosis remains poor. This is likely due to lack of early detection and only recent developments in selective cancer therapies. Key immune cells involved in the pathogenesis of lung cancer include CD4+ T lymphocytes, macrophages, dendritic cells and NK cells. The growing understanding of these cells indicates a highly complex and intertwined network of their involvement in each stage of lung cancer. Immune cell types and numbers affect prognosis and could offer an opportunity for clinical therapeutic applications. However, an incomplete understanding of immune cell involvement and the underlying processes in lung cancer still remain. Deeper investigation focusing on the role of the immune cells will further the understanding of lung carcinogenesis and develop novel therapeutic approaches for the treatment and management of patients with more specialized and selective lung cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=84911119625&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2014.975692
DO - 10.1586/1744666X.2014.975692
M3 - Review article
C2 - 25351434
AN - SCOPUS:84911119625
VL - 10
SP - 1711
EP - 1730
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 12
ER -