Cellular pathology of amygdala neurons in human temporal lobe epilepsy

Ales F. Aliashkevich, Deniz Yilmazer-Hanke, Dirk Van Roost, Björn Mundhenk, Johannes Schramm, Ingmar Blümcke

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The amygdala complex substantially contributes to the generation and propagation of focal seizures in patients suffering from temporal lobe epilepsy (TLE). A cellular substrate for increased excitability in the human amygdala, however, remains to be identified. Here, we analyzed the three-dimensional morphology of 264 neurons from different subregions of the amygdaloid complex obtained from 17 "en bloc" resected surgical specimens using intracellular Lucifer Yellow (LY) injection and confocal laser scanning microscopy. Autopsy samples from unaffected individuals (n=3, 20 neurons) served as controls. We have identified spine-laden, spine-sparse and aspinous cells in the lateral, basal, accessory basal and granular nuclei. Semiquantitative analysis points to significant changes in neuronal soma size, number of dendrites and spine densities in specimens from epilepsy patients compared to controls. Neuronal somata in the epilepsy group were smaller compared to controls (P

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalActa Neuropathologica
Volume106
Issue number2
DOIs
StatePublished - Aug 2 2003
Externally publishedYes

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Temporal Lobe Epilepsy
Amygdala
Spine
Carisoprodol
Pathology
Neurons
Epilepsy
Dendrites
Confocal Microscopy
Autopsy
Seizures
Injections

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Aliashkevich, A. F., Yilmazer-Hanke, D., Van Roost, D., Mundhenk, B., Schramm, J., & Blümcke, I. (2003). Cellular pathology of amygdala neurons in human temporal lobe epilepsy. Acta Neuropathologica, 106(2), 99-106. https://doi.org/10.1007/s00401-003-0707-0

Cellular pathology of amygdala neurons in human temporal lobe epilepsy. / Aliashkevich, Ales F.; Yilmazer-Hanke, Deniz; Van Roost, Dirk; Mundhenk, Björn; Schramm, Johannes; Blümcke, Ingmar.

In: Acta Neuropathologica, Vol. 106, No. 2, 02.08.2003, p. 99-106.

Research output: Contribution to journalArticle

Aliashkevich, AF, Yilmazer-Hanke, D, Van Roost, D, Mundhenk, B, Schramm, J & Blümcke, I 2003, 'Cellular pathology of amygdala neurons in human temporal lobe epilepsy', Acta Neuropathologica, vol. 106, no. 2, pp. 99-106. https://doi.org/10.1007/s00401-003-0707-0
Aliashkevich AF, Yilmazer-Hanke D, Van Roost D, Mundhenk B, Schramm J, Blümcke I. Cellular pathology of amygdala neurons in human temporal lobe epilepsy. Acta Neuropathologica. 2003 Aug 2;106(2):99-106. https://doi.org/10.1007/s00401-003-0707-0
Aliashkevich, Ales F. ; Yilmazer-Hanke, Deniz ; Van Roost, Dirk ; Mundhenk, Björn ; Schramm, Johannes ; Blümcke, Ingmar. / Cellular pathology of amygdala neurons in human temporal lobe epilepsy. In: Acta Neuropathologica. 2003 ; Vol. 106, No. 2. pp. 99-106.
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