Cetirizine: a new H1 antagonist with antieosinophilic activity in chronic urticaria.

R. G. Townley

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Although the action of H1 antagonists in the early phase of IgE-mediated, allergic skin reactions is well established, the effect of these antihistamines on the ensuing late-phase reaction has only recently been investigated. The eosinophilic late-phase reaction, sometimes associated with the tissue damage that occurs in chronic idiopathic urticaria, is important in allergic responses. Cetirizine is a new H1 antagonist with potent inhibitory action against the infiltration of eosinophils into involved tissue, thereby affecting the late-phase reaction. No other antihistamine has yet been reported to possess this antieosinophilic property. The mechanisms by which cetirizine acts against eosinophils, although not thoroughly understood, seem to involve direct action against these cells.

Original languageEnglish
Pages (from-to)668-674
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume25
Issue number4
StatePublished - Oct 1991

Fingerprint

Cetirizine
Histamine Antagonists
Urticaria
Eosinophils
Immunoglobulin E
Hypersensitivity
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Cetirizine : a new H1 antagonist with antieosinophilic activity in chronic urticaria. / Townley, R. G.

In: Journal of the American Academy of Dermatology, Vol. 25, No. 4, 10.1991, p. 668-674.

Research output: Contribution to journalReview article

@article{681be8ca755245299be64ce264ea29b9,
title = "Cetirizine: a new H1 antagonist with antieosinophilic activity in chronic urticaria.",
abstract = "Although the action of H1 antagonists in the early phase of IgE-mediated, allergic skin reactions is well established, the effect of these antihistamines on the ensuing late-phase reaction has only recently been investigated. The eosinophilic late-phase reaction, sometimes associated with the tissue damage that occurs in chronic idiopathic urticaria, is important in allergic responses. Cetirizine is a new H1 antagonist with potent inhibitory action against the infiltration of eosinophils into involved tissue, thereby affecting the late-phase reaction. No other antihistamine has yet been reported to possess this antieosinophilic property. The mechanisms by which cetirizine acts against eosinophils, although not thoroughly understood, seem to involve direct action against these cells.",
author = "Townley, {R. G.}",
year = "1991",
month = "10",
language = "English",
volume = "25",
pages = "668--674",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Cetirizine

T2 - a new H1 antagonist with antieosinophilic activity in chronic urticaria.

AU - Townley, R. G.

PY - 1991/10

Y1 - 1991/10

N2 - Although the action of H1 antagonists in the early phase of IgE-mediated, allergic skin reactions is well established, the effect of these antihistamines on the ensuing late-phase reaction has only recently been investigated. The eosinophilic late-phase reaction, sometimes associated with the tissue damage that occurs in chronic idiopathic urticaria, is important in allergic responses. Cetirizine is a new H1 antagonist with potent inhibitory action against the infiltration of eosinophils into involved tissue, thereby affecting the late-phase reaction. No other antihistamine has yet been reported to possess this antieosinophilic property. The mechanisms by which cetirizine acts against eosinophils, although not thoroughly understood, seem to involve direct action against these cells.

AB - Although the action of H1 antagonists in the early phase of IgE-mediated, allergic skin reactions is well established, the effect of these antihistamines on the ensuing late-phase reaction has only recently been investigated. The eosinophilic late-phase reaction, sometimes associated with the tissue damage that occurs in chronic idiopathic urticaria, is important in allergic responses. Cetirizine is a new H1 antagonist with potent inhibitory action against the infiltration of eosinophils into involved tissue, thereby affecting the late-phase reaction. No other antihistamine has yet been reported to possess this antieosinophilic property. The mechanisms by which cetirizine acts against eosinophils, although not thoroughly understood, seem to involve direct action against these cells.

UR - http://www.scopus.com/inward/record.url?scp=0025917920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025917920&partnerID=8YFLogxK

M3 - Review article

C2 - 1686439

AN - SCOPUS:0025917920

VL - 25

SP - 668

EP - 674

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 4

ER -