TY - JOUR
T1 - Changes in body weight and adiposity predict periodontitis progression in men
AU - Gorman, A.
AU - Kaye, E. K.
AU - Nunn, M.
AU - Garcia, R. I.
N1 - Funding Information:
This work was supported by National Institute of Dental and Craniofacial Research R01 DE019833 and K24 DE00419 . The Dental Longitudinal Study and Normative Aging Study are components of the Massachusetts Veterans Epidemiology Research and Information Center, which is supported by the US Department of Veterans Affairs Cooperative Studies Program. Dr. Garcia was a recipient of a Veterans Affairs Career Development Award in Health Services Research from the VA HSRD Service. Views expressed in this paper are those of the authors and do not necessarily represent the views of the US Department of Veterans Affairs.
PY - 2012/10
Y1 - 2012/10
N2 - Most studies linking obesity and periodontal disease have been cross-sectional in design. We examined whether gains in body weight, waist circumference, and arm fat area are associated with periodontitis progression in 893 non-diabetic men followed for up to four decades in the prospective VA Dental Longitudinal Study. Probing pocket depth (PPD) was measured by calibrated examiners. Repeated-measures generalized linear models estimated the mean cumulative numbers of teeth with PPD events (PPD > 3 mm) at each dental examination and the slopes associated with increasing numbers of affected teeth over time. Means were adjusted for baseline PPD, education, and cigarette pack-years, and time-dependent values of age, mean plaque score, cigarette packs/day, brushing, and flossing. Men who were overweight at baseline and gained weight most rapidly (> 0.19 kg/yr or ∼15 lb during follow-up) had significantly more PPD events than men in the lowest tertile of weight gain (≥ -0.05 kg/yr). Overweight men whose waist circumference increased > 0.14-0.39 or > 0.39 cm/yr experienced more PPD events than men in the lowest tertile (≥ 0.14 cm/yr). Increase in arm fat area was associated with disease progression in normal-weight men. These results suggest that tracking adiposity changes with easily obtained anthropometric measures may help predict risk of periodontitis progression.
AB - Most studies linking obesity and periodontal disease have been cross-sectional in design. We examined whether gains in body weight, waist circumference, and arm fat area are associated with periodontitis progression in 893 non-diabetic men followed for up to four decades in the prospective VA Dental Longitudinal Study. Probing pocket depth (PPD) was measured by calibrated examiners. Repeated-measures generalized linear models estimated the mean cumulative numbers of teeth with PPD events (PPD > 3 mm) at each dental examination and the slopes associated with increasing numbers of affected teeth over time. Means were adjusted for baseline PPD, education, and cigarette pack-years, and time-dependent values of age, mean plaque score, cigarette packs/day, brushing, and flossing. Men who were overweight at baseline and gained weight most rapidly (> 0.19 kg/yr or ∼15 lb during follow-up) had significantly more PPD events than men in the lowest tertile of weight gain (≥ -0.05 kg/yr). Overweight men whose waist circumference increased > 0.14-0.39 or > 0.39 cm/yr experienced more PPD events than men in the lowest tertile (≥ 0.14 cm/yr). Increase in arm fat area was associated with disease progression in normal-weight men. These results suggest that tracking adiposity changes with easily obtained anthropometric measures may help predict risk of periodontitis progression.
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U2 - 10.1177/0022034512457372
DO - 10.1177/0022034512457372
M3 - Article
C2 - 22895511
AN - SCOPUS:84866508213
VL - 91
SP - 921
EP - 926
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 10
ER -