Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy

Susan L. Greenspan, Subashan Perera, Robert R. Recker, Julie M. Wagner, Parmatma Greeley, Bryon R. Gomberg, Pamela Seaman, Michael Kleerekoper

Research output: Contribution to journalArticle

23 Scopus citations


Purpose: In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy. Materials and methods: We followed 10 postmenopausal women receiving a bisphosphonate, risedronate (35 mg once weekly), over 12 months and examined trabecular microarchitecture with high resolution wrist MR images (hr-MRI). MRI parameters included bone volume/total volume (BV/TV), surface density (representing plates), curve density (representing rods), surface-to-curve ratio and erosion index (depicting deterioration). We assessed BMD of the spine, hip and radius and markers of bone turnover. Results: Women had been receiving bisphosphonate therapy for 43±9 months (mean±SD) prior to the first MRI. Indices of hr-MRI demonstrated improvement in surface-to-curve ratio (13.0%) and a decrease in erosion index (12.1%) consistent with less deterioration (both p

Original languageEnglish
Pages (from-to)1006-1010
Number of pages5
Issue number4
Publication statusPublished - Apr 2010


All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Greenspan, S. L., Perera, S., Recker, R. R., Wagner, J. M., Greeley, P., Gomberg, B. R., ... Kleerekoper, M. (2010). Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy. Bone, 46(4), 1006-1010.