Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects

Janee Gelineau-van Waes, K. A. Voss, V. L. Stevens, M. C. Speer, R. T. Riley

Research output: Chapter in Book/Report/Conference proceedingChapter

56 Citations (Scopus)

Abstract

Fumonisins are mycotoxins produced by the fungus F. verticillioides, a common contaminant of maize (corn) worldwide. Maternal consumption of fumonisin B1-contaminated maize during early pregnancy has recently been associated with increased risk for neural tube defects (NTDs) in human populations that rely heavily on maize as a dietary staple. Experimental administration of purified fumonisin to mice early in gestation also results in an increased incidence of NTDs in exposed offspring. Fumonisin inhibits the enzyme ceramide synthase in de novo sphingolipid biosynthesis, resulting in an elevation of free sphingoid bases and depletion of downstream glycosphingolipids. Increased sphingoid base metabolites (i.e., sphinganine-1-phosphate) may perturb signaling cascades involved in embryonic morphogenesis by functioning as ligands for sphingosine-1-P (S1P) receptors, a family of G-protein-coupled receptors that regulate key biological processes such as cell survival/proliferation, differentiation and migration. Fumonisin-induced depletion of glycosphingolipids impairs expression and function of the GPI-anchored folate receptor (Folr1), which may also contribute to adverse pregnancy outcomes. NTDs appear to be multifactorial in origin, involving complex gene-nutrient-environment interactions. Vitamin supplements containing folic acid have been shown to reduce the occurrence of NTDs, and may help protect the developing fetus from environmental teratogens. Fumonisins appear to be an environmental risk factor for birth defects, although other aspects of maternal nutrition and genetics play interactive roles in determining pregnancy outcome. Minimizing exposures to mycotoxins through enhanced agricultural practices, identifying biomarkers of exposure, characterizing mechanisms of toxicity, and improving maternal nutrition are all important strategies for reducing the NTD burden in susceptible human populations.

Original languageEnglish
Title of host publicationAdvances in Food and Nutrition Research
Pages145-181
Number of pages37
Volume56
DOIs
StatePublished - 2009
Externally publishedYes

Publication series

NameAdvances in Food and Nutrition Research
Volume56
ISSN (Print)10434526

Fingerprint

Fumonisins
neural tube defects
Maternal Exposure
Neural Tube Defects
fumonisins
risk factors
Zea mays
glycosphingolipids
Glycosphingolipids
pregnancy outcome
maternal nutrition
corn
GPI-Anchored Folate Receptors
Mycotoxins
Mothers
Pregnancy Outcome
folic acid
human population
mycotoxins
pregnancy

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Gelineau-van Waes, J., Voss, K. A., Stevens, V. L., Speer, M. C., & Riley, R. T. (2009). Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. In Advances in Food and Nutrition Research (Vol. 56, pp. 145-181). (Advances in Food and Nutrition Research; Vol. 56). https://doi.org/10.1016/S1043-4526(08)00605-0

Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. / Gelineau-van Waes, Janee; Voss, K. A.; Stevens, V. L.; Speer, M. C.; Riley, R. T.

Advances in Food and Nutrition Research. Vol. 56 2009. p. 145-181 (Advances in Food and Nutrition Research; Vol. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gelineau-van Waes, J, Voss, KA, Stevens, VL, Speer, MC & Riley, RT 2009, Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. in Advances in Food and Nutrition Research. vol. 56, Advances in Food and Nutrition Research, vol. 56, pp. 145-181. https://doi.org/10.1016/S1043-4526(08)00605-0
Gelineau-van Waes J, Voss KA, Stevens VL, Speer MC, Riley RT. Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. In Advances in Food and Nutrition Research. Vol. 56. 2009. p. 145-181. (Advances in Food and Nutrition Research). https://doi.org/10.1016/S1043-4526(08)00605-0
Gelineau-van Waes, Janee ; Voss, K. A. ; Stevens, V. L. ; Speer, M. C. ; Riley, R. T. / Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. Advances in Food and Nutrition Research. Vol. 56 2009. pp. 145-181 (Advances in Food and Nutrition Research).
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