Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões, J. P. Rasigade, H. Lemriss, M. Butin, C. Ginevra, S. Lemriss, Richard V. Goering, A. Ibrahimi, J. C. Picaud, S. El Kabbaj, F. Vandenesch, F. Laurent

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Abstract

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

Original languageEnglish
Pages (from-to)6354-6357
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number12
DOIs
Publication statusPublished - Dec 2013

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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