Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões, J. P. Rasigade, H. Lemriss, M. Butin, C. Ginevra, S. Lemriss, Richard V. Goering, A. Ibrahimi, J. C. Picaud, S. El Kabbaj, F. Vandenesch, F. Laurent

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

Original languageEnglish
Pages (from-to)6354-6357
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Staphylococcus
Chromosomes
Arsenic
Bacteremia
Cadmium
Premature Infants
Staphylococcus aureus
Copper
Genome
Genes
Neonatal Sepsis

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A. / Simões, P. Martins; Rasigade, J. P.; Lemriss, H.; Butin, M.; Ginevra, C.; Lemriss, S.; Goering, Richard V.; Ibrahimi, A.; Picaud, J. C.; El Kabbaj, S.; Vandenesch, F.; Laurent, F.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 12, 12.2013, p. 6354-6357.

Research output: Contribution to journalArticle

Simões, PM, Rasigade, JP, Lemriss, H, Butin, M, Ginevra, C, Lemriss, S, Goering, RV, Ibrahimi, A, Picaud, JC, El Kabbaj, S, Vandenesch, F & Laurent, F 2013, 'Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A', Antimicrobial Agents and Chemotherapy, vol. 57, no. 12, pp. 6354-6357. https://doi.org/10.1128/AAC.01576-13
Simões, P. Martins ; Rasigade, J. P. ; Lemriss, H. ; Butin, M. ; Ginevra, C. ; Lemriss, S. ; Goering, Richard V. ; Ibrahimi, A. ; Picaud, J. C. ; El Kabbaj, S. ; Vandenesch, F. ; Laurent, F. / Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 12. pp. 6354-6357.
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