Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões, J. P. Rasigade, H. Lemriss, M. Butin, C. Ginevra, S. Lemriss, R. V. Goering, A. Ibrahimi, J. C. Picaud, S. El Kabbaj, F. Vandenesch, F. Laurent

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

Original languageEnglish (US)
Pages (from-to)6354-6357
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number12
DOIs
StatePublished - Dec 1 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Simões, P. M., Rasigade, J. P., Lemriss, H., Butin, M., Ginevra, C., Lemriss, S., Goering, R. V., Ibrahimi, A., Picaud, J. C., El Kabbaj, S., Vandenesch, F., & Laurent, F. (2013). Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A. Antimicrobial agents and chemotherapy, 57(12), 6354-6357. https://doi.org/10.1128/AAC.01576-13