Characterization of clonality of Epstein-Barr virus-induced human B lymphoproliferative disease in mice with severe combined immunodeficiency

Hirokazu Nakamine, Aneal S. Masih, Motohiko Okano, Yuichi Taguchi, Samuel J. Pirruccello, Jack R. Davis, Mark L. Mahloch, Kirk Beisel, Kimberly Kleveland, Warren G. Sanger, David T. Purtilo

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Abstract

To improve the diagnostic accuracy and understanding of the pathogenesis of lymphoproliferative diseases (LPDs) occurring in immunosuppressed transplant recipients (post-transplantation LPD), clonality of Epstein-Barr virus-induced human LPDs in mice with severe combined immunodeficiency was examined by analyzing: 1) human immunoglobulin genes and their products, 2) the clonality of Epstein-Barr virus DNA, and 3) genetic alteration of c-myc or bcl-2 genes. A spectrum of clonality was found in the LPDs comparable with that reported for post-transplantation LPDs, although rearrangements of c-myc or bcl-2 genes were not detected. It is confirmed that this system is useful in terms of clonality for understanding the early phases in the pathogenesis of post-transplantation LPD or LPD in immune deficient patients.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalAmerican Journal of Pathology
Volume142
Issue number1
Publication statusPublished - Jan 1993
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Nakamine, H., Masih, A. S., Okano, M., Taguchi, Y., Pirruccello, S. J., Davis, J. R., ... Purtilo, D. T. (1993). Characterization of clonality of Epstein-Barr virus-induced human B lymphoproliferative disease in mice with severe combined immunodeficiency. American Journal of Pathology, 142(1), 139-147.