Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States hospitals

Fred C. Tenover, Isabella A. Tickler, Richard V. Goering, Barry N. Kreiswirth, José R. Mediavilla, David H. Persinga

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

A total of 299 nares and 194 blood isolates of methicillin-resistant Staphylococcus aureus (MRSA), each recovered from a unique patient, were collected from 23 U.S. hospitals from May 2009 to March 2010. All isolates underwent spa and staphylococcal cassette chromosome mec element (SCCmec) typing and antimicrobial susceptibility testing; a subset of 84 isolates was typed by pulsed-field gel electrophoresis (PFGE) using SmaI. Seventy-six spa types were observed among the isolates. Overall, for nasal isolates, spa type t002-SCCmec type II (USA100) was the most common strain type (37% of isolates), while among blood isolates, spa type t008-SCCmec type IV (USA300) was the most common (39%). However, the proportion of all USA100 and USA300 isolates varied by United States census region. Nasal isolates were more resistant to tobramycin and clindamycin than blood isolates (55.9% and 48.8% of isolates versus 36.6% and 39.7%, respectively; for both, P

Original languageEnglish
Pages (from-to)1324-1330
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number3
DOIs
StatePublished - Mar 2012

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State Hospitals
Methicillin-Resistant Staphylococcus aureus
Nose
Chromosomes
Tobramycin
Clindamycin
Pulsed Field Gel Electrophoresis
Censuses
Blood Culture

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States hospitals. / Tenover, Fred C.; Tickler, Isabella A.; Goering, Richard V.; Kreiswirth, Barry N.; Mediavilla, José R.; Persinga, David H.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 3, 03.2012, p. 1324-1330.

Research output: Contribution to journalArticle

Tenover, Fred C. ; Tickler, Isabella A. ; Goering, Richard V. ; Kreiswirth, Barry N. ; Mediavilla, José R. ; Persinga, David H. / Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States hospitals. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 3. pp. 1324-1330.
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