Chick hair cells do not exhibit voltage-dependent somatic motility

David Z.Z. He, Kirk W. Beisel, Lin Chen, Da Lian Ding, Shuping Jia, Bernd Fritzsch, Richard Salvi

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

It is generally believed that mechanical amplification by cochlear hair cells is necessary to enhance the sensitivity and frequency selectivity of hearing. In the mammalian ear, the basis of cochlear amplification is believed to be the voltage-dependent electromotility of outer hair cells (OHCs). The avian basilar papilla contains tall and short hair cells, with the former being comparable to inner hair cells, and the latter comparable to OHCs, based on their innervation patterns. In this study, we sought evidence for somatic electromotility by direct measurements of voltage-dependent length changes in both tall and short hair cells at nanometre resolution. Microchamber and whole-cell voltage-clamp techniques were used. Motility was measured with a photodiode-based measurement system. Non-linear capacitance, an electrical signature of somatic motility, was also measured to complement motility measurement. Significantly, chick hair cells did not exhibit somatic motility nor express non-linear capacitance. The lack of somatic motility suggests that in avian hair cells the active process resides elsewhere, most likely in the hair cell stereocilia.

Original languageEnglish (US)
Pages (from-to)511-520
Number of pages10
JournalJournal of Physiology
Volume546
Issue number2
DOIs
StatePublished - Jan 15 2003

All Science Journal Classification (ASJC) codes

  • Physiology

Fingerprint Dive into the research topics of 'Chick hair cells do not exhibit voltage-dependent somatic motility'. Together they form a unique fingerprint.

  • Cite this

    He, D. Z. Z., Beisel, K. W., Chen, L., Ding, D. L., Jia, S., Fritzsch, B., & Salvi, R. (2003). Chick hair cells do not exhibit voltage-dependent somatic motility. Journal of Physiology, 546(2), 511-520. https://doi.org/10.1113/jphysiol.2002.026070