Chlamydia pneumoniae and occlusive vascular disease: Identification and characterization

Jeevan Pai, Floyd C. Knoop, William J. Hunter, Devendra K. Agrawal

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Chlamydia pneumoniae, a respiratory pathogen, has been associated with occlusive vascular disease, including atherosclerosis and intimal hyperplasia, through seroepidemiologic studies. Furthermore, using immunohistochemistiy (IHC), polymerase chain reaction (PCR), transmission electron microscopy (TEM), and in situ hybridization, this association has been reconfirmed by detecting this organism in atherosclerotic vascular tissue. This review summarizes and critically analyzes these findings and also discusses various mechanisms of how Chlamydia pneumoniae could be involved in the pathogenesis of occlusive vascular disease. Although more studies are needed to reproduce these results and, possibly, uncover a mechanism, the current literature fails to include detailed methodologies for studying Chlamydia pneumoniae. Therefore, to provide a general standard, we have also outlined specific protocols for IHC, PCR, and TEM. These protocols incorporate essential components from various studies and are presented in a concise and easily adaptable format.

Original languageEnglish (US)
Pages (from-to)51-61
Number of pages11
JournalJournal of Pharmacological and Toxicological Methods
Issue number1
StatePublished - Feb 1998

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology


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