Chlamydia pneumoniae and occlusive vascular disease

Identification and characterization

Jeevan Pai, Floyd C. Knoop, William J. Hunter, Devendra K. Agrawal

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Chlamydia pneumoniae, a respiratory pathogen, has been associated with occlusive vascular disease, including atherosclerosis and intimal hyperplasia, through seroepidemiologic studies. Furthermore, using immunohistochemistiy (IHC), polymerase chain reaction (PCR), transmission electron microscopy (TEM), and in situ hybridization, this association has been reconfirmed by detecting this organism in atherosclerotic vascular tissue. This review summarizes and critically analyzes these findings and also discusses various mechanisms of how Chlamydia pneumoniae could be involved in the pathogenesis of occlusive vascular disease. Although more studies are needed to reproduce these results and, possibly, uncover a mechanism, the current literature fails to include detailed methodologies for studying Chlamydia pneumoniae. Therefore, to provide a general standard, we have also outlined specific protocols for IHC, PCR, and TEM. These protocols incorporate essential components from various studies and are presented in a concise and easily adaptable format.

Original languageEnglish
Pages (from-to)51-61
Number of pages11
JournalJournal of Pharmacological and Toxicological Methods
Volume39
Issue number1
DOIs
StatePublished - Feb 1998

Fingerprint

Chlamydophila pneumoniae
Polymerase chain reaction
Vascular Diseases
Transmission electron microscopy
Transmission Electron Microscopy
Pathogens
Tunica Intima
Polymerase Chain Reaction
Seroepidemiologic Studies
Tissue
Hyperplasia
In Situ Hybridization
Blood Vessels
Atherosclerosis

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Toxicology

Cite this

Chlamydia pneumoniae and occlusive vascular disease : Identification and characterization. / Pai, Jeevan; Knoop, Floyd C.; Hunter, William J.; Agrawal, Devendra K.

In: Journal of Pharmacological and Toxicological Methods, Vol. 39, No. 1, 02.1998, p. 51-61.

Research output: Contribution to journalArticle

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