Chloride channel expression and functional diversity in the immune cells of allergic diseases

Gang Cheng, Ajeeth Ramanathan, Zhifei Shao, Devendra K. Agrawal

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalCurrent Molecular Medicine
Volume8
Issue number5
DOIs
StatePublished - Aug 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Fingerprint Dive into the research topics of 'Chloride channel expression and functional diversity in the immune cells of allergic diseases'. Together they form a unique fingerprint.

  • Cite this