Chloride channel expression and functional diversity in the immune cells of allergic diseases

Gang Cheng, Ajeeth Ramanathan, Zhifei Shao, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    8 Scopus citations

    Abstract

    Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.

    Original languageEnglish
    Pages (from-to)401-407
    Number of pages7
    JournalCurrent Molecular Medicine
    Volume8
    Issue number5
    DOIs
    StatePublished - Aug 2008

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology
    • Molecular Medicine

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