Chloride channel expression and functional diversity in the immune cells of allergic diseases

Gang Cheng, Ajeeth Ramanathan, Zhifei Shao, Devendra K. Agrawal

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalCurrent Molecular Medicine
Volume8
Issue number5
DOIs
StatePublished - Aug 2008

Fingerprint

Chloride Channels
Asthma
Apoptosis
Allergies
T-cells
Infiltration
Physiological Phenomena
Repair
Chemical activation
Eosinophils
Mast Cells
Cell Movement
Hypersensitivity
Neutrophils
Epithelium
Cell Proliferation
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Chloride channel expression and functional diversity in the immune cells of allergic diseases. / Cheng, Gang; Ramanathan, Ajeeth; Shao, Zhifei; Agrawal, Devendra K.

In: Current Molecular Medicine, Vol. 8, No. 5, 08.2008, p. 401-407.

Research output: Contribution to journalReview article

@article{d101f572be4a4c7da90731260a173c30,
title = "Chloride channel expression and functional diversity in the immune cells of allergic diseases",
abstract = "Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.",
author = "Gang Cheng and Ajeeth Ramanathan and Zhifei Shao and Agrawal, {Devendra K.}",
year = "2008",
month = "8",
doi = "10.2174/156652408785160934",
language = "English",
volume = "8",
pages = "401--407",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Chloride channel expression and functional diversity in the immune cells of allergic diseases

AU - Cheng, Gang

AU - Ramanathan, Ajeeth

AU - Shao, Zhifei

AU - Agrawal, Devendra K.

PY - 2008/8

Y1 - 2008/8

N2 - Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.

AB - Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.

UR - http://www.scopus.com/inward/record.url?scp=53849120918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53849120918&partnerID=8YFLogxK

U2 - 10.2174/156652408785160934

DO - 10.2174/156652408785160934

M3 - Review article

VL - 8

SP - 401

EP - 407

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 5

ER -