Abstract
Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 401-407 |
| Number of pages | 7 |
| Journal | Current Molecular Medicine |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 2008 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Molecular Medicine
Cite this
Chloride channel expression and functional diversity in the immune cells of allergic diseases. / Cheng, Gang; Ramanathan, Ajeeth; Shao, Zhifei; Agrawal, Devendra K.
In: Current Molecular Medicine, Vol. 8, No. 5, 08.2008, p. 401-407.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chloride channel expression and functional diversity in the immune cells of allergic diseases
AU - Cheng, Gang
AU - Ramanathan, Ajeeth
AU - Shao, Zhifei
AU - Agrawal, Devendra K.
PY - 2008/8
Y1 - 2008/8
N2 - Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
AB - Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=53849120918&partnerID=8YFLogxK
U2 - 10.2174/156652408785160934
DO - 10.2174/156652408785160934
M3 - Review article
C2 - 18691067
AN - SCOPUS:53849120918
VL - 8
SP - 401
EP - 407
JO - Current Molecular Medicine
JF - Current Molecular Medicine
SN - 1566-5240
IS - 5
ER -