Chlorothiazide—a survey of its effects in hypertensive patients

Carl C. Bartels, James A. Evans, Robert G. Townley

Research output: Contribution to journalArticle

Abstract

A definite hypotensive effect from chlorothiazide was observed in 80 % of 65 patients studied. This was more pronounced in those with severe hypertension and in those receiving ganglionic blocking agents. Of the 23 patients who had formerly required ganglionic blocking agents, 12 were able to discontinue that therapy. It would seem that periodic determinations of the serum potassium level are necessary in any patient who is receiving chlorothiazide on a long-term basis. Twenty-eight patients (43%) in this group showed a drop in potassium level to 3.5 mEq. per liter or below. This occurred in 12 despite the concurrent administration of 2 to 3 Gm. of potassium chloride daily. It is now well recognized that renal lesions may accompany potassium deficiency in man. Symptoms of this may be minimal and their onset insidious. There is also danger of hypokalemia potentiating digitalis poisoning.

Original languageEnglish
Pages (from-to)1796-1802
Number of pages7
JournalJAMA - Journal of the American Medical Association
Volume170
Issue number15
DOIs
StatePublished - Aug 8 1959
Externally publishedYes

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Ganglionic Blockers
Chlorothiazide
Potassium
Potassium Deficiency
Potassium Chloride
Hypokalemia
Digitalis
Poisoning
Hypertension
Kidney
Surveys and Questionnaires
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chlorothiazide—a survey of its effects in hypertensive patients. / Bartels, Carl C.; Evans, James A.; Townley, Robert G.

In: JAMA - Journal of the American Medical Association, Vol. 170, No. 15, 08.08.1959, p. 1796-1802.

Research output: Contribution to journalArticle

Bartels, Carl C. ; Evans, James A. ; Townley, Robert G. / Chlorothiazide—a survey of its effects in hypertensive patients. In: JAMA - Journal of the American Medical Association. 1959 ; Vol. 170, No. 15. pp. 1796-1802.
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