Choice of study phenotype in osteoporosis genetic research

Yuan Chen, Hui Shen, Fang Yang, Peng Yuan Liu, Nelson Tang, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Osteoporosis is a common disease characterized by compromised bone strength predisposing a person to an increased risk of osteoporotic fracture (OF). Recently, extensive efforts have been made to identify candidate genes underlying osteoporosis by the use of surrogate phenotypes, such as bone mineral density (BMD) and bone geometry. Among them, BMD is a suitable choice if we aim to classify the role of biological pathways for bone strength and to understand the bone conditions in the development of osteoporosis. However, evidences show that the genetic correlation between BMD and OF is very limited. In this review, we are mainly concerned with an important issue, i.e., phenotype choice in osteoporosis genetic research. For clarity, we address this issue with several arguments, and comments are made on most representative literature.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Volume27
Issue number2
DOIs
StatePublished - Mar 2009

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All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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