Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density

Feng Pan, Peng Xiao, Yan Guo, Yong Jun Liu, Hong Yi Deng, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Late age at menarche (AAM), an important type of endocrinopathy in females, is associated with lower bone mineral density (BMD), a major risk factor for osteoporosis. The correlation is mainly mediated through common genetic factors, which are largely unknown. A bivariate genome-wide linkage scan was conducted on 2,522 females from 414 Caucasian pedigrees to identify quantitative trait loci influencing both AAM and BMD. The strongest linkage signal was detected on chromosome 22q13. Other regions such as the 3q13, 3p25, 7p15, and 15q13 were also suggested. The inferred promising candidate genes in the linkage regions may contribute to our understanding of pathogenesis of endocrinopathy and osteoporosis in females.

Original languageEnglish
Pages (from-to)419-427
Number of pages9
JournalHuman Genetics
Volume123
Issue number4
DOIs
StatePublished - May 2008

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Menarche
Quantitative Trait Loci
Bone Density
Osteoporosis
Pedigree
Chromosomes
Genome
Genes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. / Pan, Feng; Xiao, Peng; Guo, Yan; Liu, Yong Jun; Deng, Hong Yi; Recker, Robert R.; Deng, Hong Wen.

In: Human Genetics, Vol. 123, No. 4, 05.2008, p. 419-427.

Research output: Contribution to journalArticle

Pan, Feng ; Xiao, Peng ; Guo, Yan ; Liu, Yong Jun ; Deng, Hong Yi ; Recker, Robert R. ; Deng, Hong Wen. / Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. In: Human Genetics. 2008 ; Vol. 123, No. 4. pp. 419-427.
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