Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse

J. F. Bureau, Kristen M. Drescher, L. R. Pease, T. Vikoren, M. Delcroix, L. Zoecklein, M. Brahic, M. Rodriguez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex-linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2(d) (DBA/2J x B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus- induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.

Original languageEnglish
Pages (from-to)1941-1949
Number of pages9
JournalGenetics
Volume148
Issue number4
StatePublished - Apr 1998
Externally publishedYes

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Theilovirus
Chromosomes, Human, Pair 14
Demyelinating Diseases
Major Histocompatibility Complex
Viruses
Multiple Sclerosis
Chronic Disease
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Bureau, J. F., Drescher, K. M., Pease, L. R., Vikoren, T., Delcroix, M., Zoecklein, L., ... Rodriguez, M. (1998). Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. Genetics, 148(4), 1941-1949.

Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. / Bureau, J. F.; Drescher, Kristen M.; Pease, L. R.; Vikoren, T.; Delcroix, M.; Zoecklein, L.; Brahic, M.; Rodriguez, M.

In: Genetics, Vol. 148, No. 4, 04.1998, p. 1941-1949.

Research output: Contribution to journalArticle

Bureau, JF, Drescher, KM, Pease, LR, Vikoren, T, Delcroix, M, Zoecklein, L, Brahic, M & Rodriguez, M 1998, 'Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse', Genetics, vol. 148, no. 4, pp. 1941-1949.
Bureau JF, Drescher KM, Pease LR, Vikoren T, Delcroix M, Zoecklein L et al. Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. Genetics. 1998 Apr;148(4):1941-1949.
Bureau, J. F. ; Drescher, Kristen M. ; Pease, L. R. ; Vikoren, T. ; Delcroix, M. ; Zoecklein, L. ; Brahic, M. ; Rodriguez, M. / Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse. In: Genetics. 1998 ; Vol. 148, No. 4. pp. 1941-1949.
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