Chromosome instability and the FAMMM syndrome

Henry T. Lynch, Ramon M. Fusaro, Avery A. Sandberg, Helen A. Bixenman, Lavonne R. Johnsen, Jane F. Lynch, K. H. Ramesh, Mark Leppert

Research output: Contribution to journalArticle

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Abstract

Our study involved two extended familial atypical multiple mole melanoma (FAMMM) kindreds wherein a sufficient number of informative, high genetic risk, and affected patients enabled collection of pertinent tissue samples (normal skin/fibroblasts and atypical nevi/melanocytes) for cytogenetic analysis, and peripheral blood lymphocytes for DNA usage for linkage studies. We observed marked chromosome instability, as evidence by increased frequencies of cells with chromosomal rearrangements (translocations, deletions, and inversions) in cell cultures from atypical nevi and normal skin. There was no evidence of linkage of the FAMMM disease locus to any of the markers for the short arm of chromosome 1p in these two families. Well-characterized FAMMM kindreds provide an opportunity for biomarker investigations for elucidating heterogeneity and, ultimately, improving cancer control.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalCancer Genetics and Cytogenetics
Volume71
Issue number1
DOIs
StatePublished - 1993

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Dysplastic Nevus Syndrome
Chromosomal Instability
Nevus
Genetic Translocation
Skin
Cytogenetic Analysis
Melanocytes
Cell Culture Techniques
Fibroblasts
Chromosomes
Biomarkers
Lymphocytes
DNA
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Lynch, H. T., Fusaro, R. M., Sandberg, A. A., Bixenman, H. A., Johnsen, L. R., Lynch, J. F., ... Leppert, M. (1993). Chromosome instability and the FAMMM syndrome. Cancer Genetics and Cytogenetics, 71(1), 27-39. https://doi.org/10.1016/0165-4608(93)90199-V

Chromosome instability and the FAMMM syndrome. / Lynch, Henry T.; Fusaro, Ramon M.; Sandberg, Avery A.; Bixenman, Helen A.; Johnsen, Lavonne R.; Lynch, Jane F.; Ramesh, K. H.; Leppert, Mark.

In: Cancer Genetics and Cytogenetics, Vol. 71, No. 1, 1993, p. 27-39.

Research output: Contribution to journalArticle

Lynch, HT, Fusaro, RM, Sandberg, AA, Bixenman, HA, Johnsen, LR, Lynch, JF, Ramesh, KH & Leppert, M 1993, 'Chromosome instability and the FAMMM syndrome', Cancer Genetics and Cytogenetics, vol. 71, no. 1, pp. 27-39. https://doi.org/10.1016/0165-4608(93)90199-V
Lynch HT, Fusaro RM, Sandberg AA, Bixenman HA, Johnsen LR, Lynch JF et al. Chromosome instability and the FAMMM syndrome. Cancer Genetics and Cytogenetics. 1993;71(1):27-39. https://doi.org/10.1016/0165-4608(93)90199-V
Lynch, Henry T. ; Fusaro, Ramon M. ; Sandberg, Avery A. ; Bixenman, Helen A. ; Johnsen, Lavonne R. ; Lynch, Jane F. ; Ramesh, K. H. ; Leppert, Mark. / Chromosome instability and the FAMMM syndrome. In: Cancer Genetics and Cytogenetics. 1993 ; Vol. 71, No. 1. pp. 27-39.
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