Chronic inflammation and cancer: Emerging roles of triggering receptors expressed on myeloid cells

Austin Huy Nguyen, Ilya Berim, Devendra K. Agrawal

Research output: Contribution to journalReview article

15 Scopus citations


Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.

Original languageEnglish
Pages (from-to)849-857
Number of pages9
JournalExpert Review of Clinical Immunology
Issue number7
Publication statusPublished - Jul 1 2015


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

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