Abstract
Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 849-857 |
| Number of pages | 9 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 11 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Medicine(all)
Cite this
Chronic inflammation and cancer : Emerging roles of triggering receptors expressed on myeloid cells. / Nguyen, Austin Huy; Berim, Ilya; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 11, No. 7, 01.07.2015, p. 849-857.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chronic inflammation and cancer
T2 - Emerging roles of triggering receptors expressed on myeloid cells
AU - Nguyen, Austin Huy
AU - Berim, Ilya
AU - Agrawal, Devendra K.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.
AB - Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84932122117&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2015.1043893
DO - 10.1586/1744666X.2015.1043893
M3 - Review article
VL - 11
SP - 849
EP - 857
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 7
ER -