Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer

P. S. Dovgan, J. D. Edwards, X. Zhan, M. Wilde, Devendra K. Agrawal

    Research output: Contribution to journalArticlepeer-review

    30 Scopus citations

    Abstract

    Leukocyte adherence to endothelium represents one of the early responses to injury. Although the underlying mechanisms of atherosclerosis and intimal hyperplasia remain unclear, monocytes/macrophages are associated with this phenomenon. Since cigarette smoking has been identified as a major risk factor for cardiovascular disease, we examined the effects of chronic cigarette smoking on human leukocyte adherence (monocytes, lymphocytes, and neutrophils) to cultured human umbilical vein endothelial cells (HUVEC's) in vitro. Among the cells, the basal adherence of monocytes only was significantly elevated in the smoking group (p

    Original languageEnglish
    Pages (from-to)929-934
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume203
    Issue number2
    DOIs
    StatePublished - 1994

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Biophysics
    • Molecular Biology

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