Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer

P. S. Dovgan, J. D. Edwards, X. Zhan, M. Wilde, Devendra K. Agrawal

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Abstract

Leukocyte adherence to endothelium represents one of the early responses to injury. Although the underlying mechanisms of atherosclerosis and intimal hyperplasia remain unclear, monocytes/macrophages are associated with this phenomenon. Since cigarette smoking has been identified as a major risk factor for cardiovascular disease, we examined the effects of chronic cigarette smoking on human leukocyte adherence (monocytes, lymphocytes, and neutrophils) to cultured human umbilical vein endothelial cells (HUVEC's) in vitro. Among the cells, the basal adherence of monocytes only was significantly elevated in the smoking group (p

Original languageEnglish
Pages (from-to)929-934
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume203
Issue number2
DOIs
Publication statusPublished - 1994

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

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