Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer

P. S. Dovgan; J. D. Edwards; X. Zhan; M. Wilde; Devendra K. Agrawal

doi:10.1006/bbrc.1994.2271

Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer

P. S. Dovgan, J. D. Edwards, X. Zhan, M. Wilde, Devendra K. Agrawal

Department of Clinical and Translational Science

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Leukocyte adherence to endothelium represents one of the early responses to injury. Although the underlying mechanisms of atherosclerosis and intimal hyperplasia remain unclear, monocytes/macrophages are associated with this phenomenon. Since cigarette smoking has been identified as a major risk factor for cardiovascular disease, we examined the effects of chronic cigarette smoking on human leukocyte adherence (monocytes, lymphocytes, and neutrophils) to cultured human umbilical vein endothelial cells (HUVEC's) in vitro. Among the cells, the basal adherence of monocytes only was significantly elevated in the smoking group (p

Original language	English
Pages (from-to)	929-934
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	203
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.2271
State	Published - 1994

All Science Journal Classification (ASJC) codes

Biochemistry
Biophysics
Molecular Biology

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Dovgan, P. S., Edwards, J. D., Zhan, X., Wilde, M., & Agrawal, D. K. (1994). Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer. Biochemical and Biophysical Research Communications, 203(2), 929-934. https://doi.org/10.1006/bbrc.1994.2271

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