TY - JOUR
T1 - Classification of solid dispersions
T2 - Correlation to (i) stability and solubility (II) preparation and characterization techniques
AU - Meng, Fan
AU - Gala, Urvi
AU - Chauhan, Harsh
N1 - Funding Information:
The author wishes to acknowledge Creighton University, Omaha for funding and the use of instruments in completing this project.
Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Solid dispersion has been a topic of interest in recent years for its potential in improving oral bioavailability, especially for poorly water soluble drugs where dissolution could be the ratelimiting step of oral absorption. Understanding the physical state of the drug and polymers in solid dispersions is essential as it influences both the stability and solubility of these systems. This review emphasizes on the classification of solid dispersions based on the physical states of drug and polymer. Based on this classification, stability aspects such as crystallization tendency, glass transition temperature (Tg), drug polymer miscibility, molecular mobility, etc. and solubility aspects have been discussed. In addition, preparation and characterization methods for binary solid dispersions based on the classification have also been discussed.
AB - Solid dispersion has been a topic of interest in recent years for its potential in improving oral bioavailability, especially for poorly water soluble drugs where dissolution could be the ratelimiting step of oral absorption. Understanding the physical state of the drug and polymers in solid dispersions is essential as it influences both the stability and solubility of these systems. This review emphasizes on the classification of solid dispersions based on the physical states of drug and polymer. Based on this classification, stability aspects such as crystallization tendency, glass transition temperature (Tg), drug polymer miscibility, molecular mobility, etc. and solubility aspects have been discussed. In addition, preparation and characterization methods for binary solid dispersions based on the classification have also been discussed.
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U2 - 10.3109/03639045.2015.1018274
DO - 10.3109/03639045.2015.1018274
M3 - Review article
C2 - 25853292
AN - SCOPUS:84964308455
VL - 41
SP - 1401
EP - 1415
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
SN - 0363-9045
IS - 9
ER -