Classification of solid dispersions: Correlation to (i) stability and solubility (II) preparation and characterization techniques

Fan Meng, Urvi Gala, Harsh Chauhan

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Solid dispersion has been a topic of interest in recent years for its potential in improving oral bioavailability, especially for poorly water soluble drugs where dissolution could be the ratelimiting step of oral absorption. Understanding the physical state of the drug and polymers in solid dispersions is essential as it influences both the stability and solubility of these systems. This review emphasizes on the classification of solid dispersions based on the physical states of drug and polymer. Based on this classification, stability aspects such as crystallization tendency, glass transition temperature (Tg), drug polymer miscibility, molecular mobility, etc. and solubility aspects have been discussed. In addition, preparation and characterization methods for binary solid dispersions based on the classification have also been discussed.

Original languageEnglish (US)
Pages (from-to)1401-1415
Number of pages15
JournalDrug Development and Industrial Pharmacy
Volume41
Issue number9
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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