Clinical and economic evaluation of the trellis rhrombectomy device for arterial occlusions: Preliminary analysis

Timur P. Sarac, Daniel E. Hilleman, Frank R. Arko, Christopher K. Zarins, Kenneth Ouriel

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objectives: This preliminary study examined the technical efficacy, safety, and cost of treating arterial occlusions with a single device that combines pharmacologic and mechanical thrombolysis. Methods: The technical success, bleeding complications, and costs for the first 26 consecutive patients in whom lower extremity ischemia was treated with the Trellis infusion catheter (TIC) were analyzed. Procedure time, thrombolytic infusion time, technical success, bleeding complications (major and intracranial hemorrhage), interventional suite time, and 30-day amputation-free survival were evaluated. Results: 15 of 26 patients (58%) who received treatment with the TIC had acute arterial occlusions, and 11 of 26 patients (42%) had nonacute arterial occlusions. Nineteen of 26 patients (73.1%) received treatment of an infrainguinal occlusion, and 7 of 26 patients (26.9%) received treatment of a suprainguinal occlusion. Lower extremity native arteries were treated in 18 of 26 patients (69%), and lower extremity bypass grafts in 8 of 26 patients (31%). The technical success rate with TIC treatment was 92%, and the 30-day amputation-free survival rate was 96%. There was no difference in technical success or amputation-free survival rate between acute versus nonacute arterial occlusions, native artery versus bypass grafts, and suprainguinal versus infrainguinal arterial occlusions. Procedure time was 2.1 ± 0.9 hours, and infusion time was 0.3 ± 0.2 hours. There were no bleeding complications; however, 3 of 26 patients (11.5%) required further intervention to treat distal embolization. The overall mean cost for patients with TIC treatment was $3216 ± $1740. Conclusions: Early results of TIC treatment in patients with arterial occlusions suggest that it is as effective as traditional catheter-directed thrombolysis. Furthermore, there were no bleeding complications, likely the result of TIC requiring shorter procedure and infusion times.

Original languageEnglish
Pages (from-to)556-559
Number of pages4
JournalJournal of Vascular Surgery
Volume39
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Cost-Benefit Analysis
Equipment and Supplies
Catheters
Amputation
Hemorrhage
Lower Extremity
Costs and Cost Analysis
Mechanical Thrombolysis
Therapeutics
Survival Rate
Arteries
Transplants
Intracranial Hemorrhages
Ischemia
Safety
Survival

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Clinical and economic evaluation of the trellis rhrombectomy device for arterial occlusions : Preliminary analysis. / Sarac, Timur P.; Hilleman, Daniel E.; Arko, Frank R.; Zarins, Christopher K.; Ouriel, Kenneth.

In: Journal of Vascular Surgery, Vol. 39, No. 3, 03.2004, p. 556-559.

Research output: Contribution to journalArticle

Sarac, Timur P. ; Hilleman, Daniel E. ; Arko, Frank R. ; Zarins, Christopher K. ; Ouriel, Kenneth. / Clinical and economic evaluation of the trellis rhrombectomy device for arterial occlusions : Preliminary analysis. In: Journal of Vascular Surgery. 2004 ; Vol. 39, No. 3. pp. 556-559.
@article{6b8633e2baaf4294a2638a3b06e5676c,
title = "Clinical and economic evaluation of the trellis rhrombectomy device for arterial occlusions: Preliminary analysis",
abstract = "Objectives: This preliminary study examined the technical efficacy, safety, and cost of treating arterial occlusions with a single device that combines pharmacologic and mechanical thrombolysis. Methods: The technical success, bleeding complications, and costs for the first 26 consecutive patients in whom lower extremity ischemia was treated with the Trellis infusion catheter (TIC) were analyzed. Procedure time, thrombolytic infusion time, technical success, bleeding complications (major and intracranial hemorrhage), interventional suite time, and 30-day amputation-free survival were evaluated. Results: 15 of 26 patients (58{\%}) who received treatment with the TIC had acute arterial occlusions, and 11 of 26 patients (42{\%}) had nonacute arterial occlusions. Nineteen of 26 patients (73.1{\%}) received treatment of an infrainguinal occlusion, and 7 of 26 patients (26.9{\%}) received treatment of a suprainguinal occlusion. Lower extremity native arteries were treated in 18 of 26 patients (69{\%}), and lower extremity bypass grafts in 8 of 26 patients (31{\%}). The technical success rate with TIC treatment was 92{\%}, and the 30-day amputation-free survival rate was 96{\%}. There was no difference in technical success or amputation-free survival rate between acute versus nonacute arterial occlusions, native artery versus bypass grafts, and suprainguinal versus infrainguinal arterial occlusions. Procedure time was 2.1 ± 0.9 hours, and infusion time was 0.3 ± 0.2 hours. There were no bleeding complications; however, 3 of 26 patients (11.5{\%}) required further intervention to treat distal embolization. The overall mean cost for patients with TIC treatment was $3216 ± $1740. Conclusions: Early results of TIC treatment in patients with arterial occlusions suggest that it is as effective as traditional catheter-directed thrombolysis. Furthermore, there were no bleeding complications, likely the result of TIC requiring shorter procedure and infusion times.",
author = "Sarac, {Timur P.} and Hilleman, {Daniel E.} and Arko, {Frank R.} and Zarins, {Christopher K.} and Kenneth Ouriel",
year = "2004",
month = "3",
doi = "10.1016/j.jvs.2003.10.061",
language = "English",
volume = "39",
pages = "556--559",
journal = "Journal of Vascular Surgery",
issn = "0741-5214",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Clinical and economic evaluation of the trellis rhrombectomy device for arterial occlusions

T2 - Preliminary analysis

AU - Sarac, Timur P.

AU - Hilleman, Daniel E.

AU - Arko, Frank R.

AU - Zarins, Christopher K.

AU - Ouriel, Kenneth

PY - 2004/3

Y1 - 2004/3

N2 - Objectives: This preliminary study examined the technical efficacy, safety, and cost of treating arterial occlusions with a single device that combines pharmacologic and mechanical thrombolysis. Methods: The technical success, bleeding complications, and costs for the first 26 consecutive patients in whom lower extremity ischemia was treated with the Trellis infusion catheter (TIC) were analyzed. Procedure time, thrombolytic infusion time, technical success, bleeding complications (major and intracranial hemorrhage), interventional suite time, and 30-day amputation-free survival were evaluated. Results: 15 of 26 patients (58%) who received treatment with the TIC had acute arterial occlusions, and 11 of 26 patients (42%) had nonacute arterial occlusions. Nineteen of 26 patients (73.1%) received treatment of an infrainguinal occlusion, and 7 of 26 patients (26.9%) received treatment of a suprainguinal occlusion. Lower extremity native arteries were treated in 18 of 26 patients (69%), and lower extremity bypass grafts in 8 of 26 patients (31%). The technical success rate with TIC treatment was 92%, and the 30-day amputation-free survival rate was 96%. There was no difference in technical success or amputation-free survival rate between acute versus nonacute arterial occlusions, native artery versus bypass grafts, and suprainguinal versus infrainguinal arterial occlusions. Procedure time was 2.1 ± 0.9 hours, and infusion time was 0.3 ± 0.2 hours. There were no bleeding complications; however, 3 of 26 patients (11.5%) required further intervention to treat distal embolization. The overall mean cost for patients with TIC treatment was $3216 ± $1740. Conclusions: Early results of TIC treatment in patients with arterial occlusions suggest that it is as effective as traditional catheter-directed thrombolysis. Furthermore, there were no bleeding complications, likely the result of TIC requiring shorter procedure and infusion times.

AB - Objectives: This preliminary study examined the technical efficacy, safety, and cost of treating arterial occlusions with a single device that combines pharmacologic and mechanical thrombolysis. Methods: The technical success, bleeding complications, and costs for the first 26 consecutive patients in whom lower extremity ischemia was treated with the Trellis infusion catheter (TIC) were analyzed. Procedure time, thrombolytic infusion time, technical success, bleeding complications (major and intracranial hemorrhage), interventional suite time, and 30-day amputation-free survival were evaluated. Results: 15 of 26 patients (58%) who received treatment with the TIC had acute arterial occlusions, and 11 of 26 patients (42%) had nonacute arterial occlusions. Nineteen of 26 patients (73.1%) received treatment of an infrainguinal occlusion, and 7 of 26 patients (26.9%) received treatment of a suprainguinal occlusion. Lower extremity native arteries were treated in 18 of 26 patients (69%), and lower extremity bypass grafts in 8 of 26 patients (31%). The technical success rate with TIC treatment was 92%, and the 30-day amputation-free survival rate was 96%. There was no difference in technical success or amputation-free survival rate between acute versus nonacute arterial occlusions, native artery versus bypass grafts, and suprainguinal versus infrainguinal arterial occlusions. Procedure time was 2.1 ± 0.9 hours, and infusion time was 0.3 ± 0.2 hours. There were no bleeding complications; however, 3 of 26 patients (11.5%) required further intervention to treat distal embolization. The overall mean cost for patients with TIC treatment was $3216 ± $1740. Conclusions: Early results of TIC treatment in patients with arterial occlusions suggest that it is as effective as traditional catheter-directed thrombolysis. Furthermore, there were no bleeding complications, likely the result of TIC requiring shorter procedure and infusion times.

UR - http://www.scopus.com/inward/record.url?scp=1542316855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542316855&partnerID=8YFLogxK

U2 - 10.1016/j.jvs.2003.10.061

DO - 10.1016/j.jvs.2003.10.061

M3 - Article

C2 - 14981448

AN - SCOPUS:1542316855

VL - 39

SP - 556

EP - 559

JO - Journal of Vascular Surgery

JF - Journal of Vascular Surgery

SN - 0741-5214

IS - 3

ER -