Clinical selection of candidates for mutational testing for cancer susceptibility.

Henry T. Lynch, Patrick M. Lynch

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Advances in molecular genetics have evolved at such a fast pace that physicians may be bewildered about their clinical translation into patient care. However, genetic counselors, particularly those trained in cancer genetics, have been extremely helpful. The challenge to the physician, however, calls for an understanding of the natural history of hereditary cancer syndromes, which is often reflected in the pedigree. Pedigree/family history information must be compiled in sufficient detail to arrive at the most likely hereditary cancer syndrome diagnosis so that the molecular geneticist can search for the mutation. Finally, the challenge to the clinician is melding this into an accurate diagnosis, in order to provide highly targeted screening and management for high-risk patients. This article is an attempt to crystallize all of these issues in a format that will help physicians-particularly those in the oncology community-to meet this challenge effectively.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalOncology
Volume20
Issue number14 Suppl 10
StatePublished - Dec 2006

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Hereditary Neoplastic Syndromes
Pedigree
Physicians
Neoplasms
Risk Management
Molecular Biology
Patient Care
Mutation

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Clinical selection of candidates for mutational testing for cancer susceptibility. / Lynch, Henry T.; Lynch, Patrick M.

In: Oncology, Vol. 20, No. 14 Suppl 10, 12.2006, p. 29-34.

Research output: Contribution to journalReview article

Lynch, Henry T. ; Lynch, Patrick M. / Clinical selection of candidates for mutational testing for cancer susceptibility. In: Oncology. 2006 ; Vol. 20, No. 14 Suppl 10. pp. 29-34.
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