Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers

André Nkondjock, Parviz Ghadirian, Joanne Kotsopoulos, Jan Lubinski, Henry T. Lynch, Charmaine Kim-Sing, Douglas Horsman, Barry Rosen, Claudine Isaacs, Barbara Weber, William Foulkes, Peter Ainsworth, Nadine Tung, Andrea Eisen, Eitan Friedman, Charis Eng, Ping Sun, Steven A. Narod

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Abstract

Although there are several plausible biologic mechanisms whereby coffee consumption might influence the risk of breast cancer, epidemiologic evidence is limited. We assessed the association between coffee consumption and breast cancer risk among high-risk women who carry BRCA mutations. We performed a matched case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries. Average lifetime coffee consumption was estimated via a self-administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for potential confounders, the ORs for breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee were 1.00, 0.90 (95% CI 0.72-1.12), 0.75 (95% CI 0.47-1.19) and 0.31 (95% CI 0.13-0.71; p-trend = 0.02). The effect was limited to the consumption of caffeinated coffee. These results suggest that among women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalInternational Journal of Cancer
Volume118
Issue number1
DOIs
StatePublished - Jan 1 2006

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Coffee
Breast Neoplasms
Mutation
Confidence Intervals
Odds Ratio
Logistic Models
Genes

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Nkondjock, A., Ghadirian, P., Kotsopoulos, J., Lubinski, J., Lynch, H. T., Kim-Sing, C., ... Narod, S. A. (2006). Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. International Journal of Cancer, 118(1), 103-107. https://doi.org/10.1002/ijc.21296

Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. / Nkondjock, André; Ghadirian, Parviz; Kotsopoulos, Joanne; Lubinski, Jan; Lynch, Henry T.; Kim-Sing, Charmaine; Horsman, Douglas; Rosen, Barry; Isaacs, Claudine; Weber, Barbara; Foulkes, William; Ainsworth, Peter; Tung, Nadine; Eisen, Andrea; Friedman, Eitan; Eng, Charis; Sun, Ping; Narod, Steven A.

In: International Journal of Cancer, Vol. 118, No. 1, 01.01.2006, p. 103-107.

Research output: Contribution to journalArticle

Nkondjock, A, Ghadirian, P, Kotsopoulos, J, Lubinski, J, Lynch, HT, Kim-Sing, C, Horsman, D, Rosen, B, Isaacs, C, Weber, B, Foulkes, W, Ainsworth, P, Tung, N, Eisen, A, Friedman, E, Eng, C, Sun, P & Narod, SA 2006, 'Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers', International Journal of Cancer, vol. 118, no. 1, pp. 103-107. https://doi.org/10.1002/ijc.21296
Nkondjock, André ; Ghadirian, Parviz ; Kotsopoulos, Joanne ; Lubinski, Jan ; Lynch, Henry T. ; Kim-Sing, Charmaine ; Horsman, Douglas ; Rosen, Barry ; Isaacs, Claudine ; Weber, Barbara ; Foulkes, William ; Ainsworth, Peter ; Tung, Nadine ; Eisen, Andrea ; Friedman, Eitan ; Eng, Charis ; Sun, Ping ; Narod, Steven A. / Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. In: International Journal of Cancer. 2006 ; Vol. 118, No. 1. pp. 103-107.
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