Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations

Chanita Hughes Halbert, Henry T. Lynch, Jane Lynch, David Main, Susan Kucharski, Anil K. Rustgi, Caryn Lerman

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P

Original languageEnglish
Pages (from-to)1881-1887
Number of pages7
JournalArchives of Internal Medicine
Volume164
Issue number17
DOIs
StatePublished - Sep 27 2004

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Genetic Testing
Early Detection of Cancer
Colonic Neoplasms
Colonoscopy
Mutation
Genetic Counseling
Colectomy
Disclosure
Telephone
Colorectal Neoplasms
Cohort Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations. / Halbert, Chanita Hughes; Lynch, Henry T.; Lynch, Jane; Main, David; Kucharski, Susan; Rustgi, Anil K.; Lerman, Caryn.

In: Archives of Internal Medicine, Vol. 164, No. 17, 27.09.2004, p. 1881-1887.

Research output: Contribution to journalArticle

Halbert, Chanita Hughes ; Lynch, Henry T. ; Lynch, Jane ; Main, David ; Kucharski, Susan ; Rustgi, Anil K. ; Lerman, Caryn. / Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations. In: Archives of Internal Medicine. 2004 ; Vol. 164, No. 17. pp. 1881-1887.
@article{42c66c5097e74d93902e499d14585a77,
title = "Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations",
abstract = "Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73{\%} (16/22) of HNPCC mutation carriers, 16{\%} (8/49) of noncarriers, and 22{\%} (6/27) of decliners reported having a colonoscopy (χ2=23.97, P",
author = "Halbert, {Chanita Hughes} and Lynch, {Henry T.} and Jane Lynch and David Main and Susan Kucharski and Rustgi, {Anil K.} and Caryn Lerman",
year = "2004",
month = "9",
day = "27",
doi = "10.1001/archinte.164.17.1881",
language = "English",
volume = "164",
pages = "1881--1887",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "17",

}

TY - JOUR

T1 - Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations

AU - Halbert, Chanita Hughes

AU - Lynch, Henry T.

AU - Lynch, Jane

AU - Main, David

AU - Kucharski, Susan

AU - Rustgi, Anil K.

AU - Lerman, Caryn

PY - 2004/9/27

Y1 - 2004/9/27

N2 - Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P

AB - Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P

UR - http://www.scopus.com/inward/record.url?scp=4644239263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644239263&partnerID=8YFLogxK

U2 - 10.1001/archinte.164.17.1881

DO - 10.1001/archinte.164.17.1881

M3 - Article

C2 - 15451763

AN - SCOPUS:4644239263

VL - 164

SP - 1881

EP - 1887

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 17

ER -