Abstract
Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P
Original language | English |
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Pages (from-to) | 1881-1887 |
Number of pages | 7 |
Journal | Archives of Internal Medicine |
Volume | 164 |
Issue number | 17 |
DOIs | |
State | Published - Sep 27 2004 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations. / Halbert, Chanita Hughes; Lynch, Henry T.; Lynch, Jane; Main, David; Kucharski, Susan; Rustgi, Anil K.; Lerman, Caryn.
In: Archives of Internal Medicine, Vol. 164, No. 17, 27.09.2004, p. 1881-1887.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations
AU - Halbert, Chanita Hughes
AU - Lynch, Henry T.
AU - Lynch, Jane
AU - Main, David
AU - Kucharski, Susan
AU - Rustgi, Anil K.
AU - Lerman, Caryn
PY - 2004/9/27
Y1 - 2004/9/27
N2 - Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P
AB - Background: Although increased colonoscopic surveillance is recommended for hereditary nonpolyposis colon cancer (HNPCC) mutation carriers, limited information is available on adherence to colorectal cancer screening recommendations. This study investigated colonoscopy practices following genetic testing for HNPCC mutations. Methods: This prospective cohort study was conducted between May 22, 1996, and November 13, 1999. Participants were 98 men and women without a personal history of colon cancer or colectomy who were identified from 11 extended HNPCC families. Colonoscopy use was evaluated by telephone before genetic counseling and was reassessed 1, 6, and 12 months following test results disclosure. Results: During the 12 months following genetic counseling and testing, 73% (16/22) of HNPCC mutation carriers, 16% (8/49) of noncarriers, and 22% (6/27) of decliners reported having a colonoscopy (χ2=23.97, P
UR - http://www.scopus.com/inward/record.url?scp=4644239263&partnerID=8YFLogxK
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U2 - 10.1001/archinte.164.17.1881
DO - 10.1001/archinte.164.17.1881
M3 - Article
C2 - 15451763
AN - SCOPUS:4644239263
VL - 164
SP - 1881
EP - 1887
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 17
ER -