Combination therapy for non-Hodgkin's lymphoma

an opportunity for pharmaceutical care in a specialty practice.

Samuel C. Augustine, Jeffrey P. Norenberg, David M. Colcher, Julie M. Vose, Lisa S. Gobar, Valorie J. Dukat, Maribeth A. Hohenstein, Frank J. Rutar, David A. Jacobson, Margaret A. Tempero

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To describe the application of pharmaceutical care practices in the administration of new therapeutic radiopharmaceuticals used in the treatment of non-Hodgkin's lymphoma (NHL). PRACTICE DESCRIPTION: At the Antibody Labeling Facility at the University of Nebraska Medical Center, the nuclear pharmacist provides support in the formulation, preparation, and quality testing of radiopharmaceuticals. The nuclear pharmacist also provides direct patient care by assisting in the administration of radiopharmaceuticals, monitoring patients during their infusions, and counseling patients on radioimmunotherapy and radiation safety. PRACTICE INNOVATION: Expanding the role of the nuclear pharmacist in treating patients with NHL using radiolabeled monoclonal antibodies (MABs). INTERVENTIONS: The nuclear pharmacist provides specialized pharmaceutical care by being involved in planning patient care, administering diagnostic and therapeutic radiopharmaceuticals, performing individualized patient dose calculations, monitoring patients, and counseling patients. MAIN OUTCOME MEASURES: Number of patients treated with radiolabeled MABs. RESULTS: Since January 1996, 85 patients with NHL have been treated using 131I-tositumomab (Corixa, GlaxoSmithKline), an anti-B1 MAB, under various clinical research protocols requiring specialized pharmaceutical care. The nuclear pharmacist on the team provided direct patient care, assisting with the administration of diagnostic and therapeutic radiopharmaceuticals under a collaborative agreement with a nuclear medicine physician or a radiation oncologist. Other pharmaceutical care activities performed include calculating individual patient doses, obtaining medication histories, counseling patients on their therapy and on radiation safety after early release, and monitoring patients for adverse effects during medication infusion. Patients have responded favorably to nontraditional nuclear pharmacy activities. CONCLUSION: The nuclear pharmacist has become an important member of the health care team that provides a new and unique therapy for patients with NHL. To date, the nuclear pharmacist, in collaboration with the nuclear medicine physician or the radiation oncologist, has successfully administered the tositumomab and 131I-tositumomab combination therapy without significant incident.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalJournal of the American Pharmaceutical Association (Washington,D.C. : 1996)
Volume42
Issue number1
StatePublished - Jan 2002
Externally publishedYes

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Pharmaceutical Services
Radiopharmaceuticals
Non-Hodgkin's Lymphoma
Patient monitoring
Pharmacists
Nuclear medicine
Radiation
Pharmaceutical Preparations
Monoclonal Antibodies
Physiologic Monitoring
Therapeutics
Counseling
Nuclear Medicine
Health care
Labeling
Patient Care
Patient Care Planning
Radioimmunotherapy
Physicians
Safety

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Combination therapy for non-Hodgkin's lymphoma : an opportunity for pharmaceutical care in a specialty practice. / Augustine, Samuel C.; Norenberg, Jeffrey P.; Colcher, David M.; Vose, Julie M.; Gobar, Lisa S.; Dukat, Valorie J.; Hohenstein, Maribeth A.; Rutar, Frank J.; Jacobson, David A.; Tempero, Margaret A.

In: Journal of the American Pharmaceutical Association (Washington,D.C. : 1996), Vol. 42, No. 1, 01.2002, p. 93-100.

Research output: Contribution to journalArticle

Augustine, SC, Norenberg, JP, Colcher, DM, Vose, JM, Gobar, LS, Dukat, VJ, Hohenstein, MA, Rutar, FJ, Jacobson, DA & Tempero, MA 2002, 'Combination therapy for non-Hodgkin's lymphoma: an opportunity for pharmaceutical care in a specialty practice.', Journal of the American Pharmaceutical Association (Washington,D.C. : 1996), vol. 42, no. 1, pp. 93-100.
Augustine, Samuel C. ; Norenberg, Jeffrey P. ; Colcher, David M. ; Vose, Julie M. ; Gobar, Lisa S. ; Dukat, Valorie J. ; Hohenstein, Maribeth A. ; Rutar, Frank J. ; Jacobson, David A. ; Tempero, Margaret A. / Combination therapy for non-Hodgkin's lymphoma : an opportunity for pharmaceutical care in a specialty practice. In: Journal of the American Pharmaceutical Association (Washington,D.C. : 1996). 2002 ; Vol. 42, No. 1. pp. 93-100.
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abstract = "OBJECTIVE: To describe the application of pharmaceutical care practices in the administration of new therapeutic radiopharmaceuticals used in the treatment of non-Hodgkin's lymphoma (NHL). PRACTICE DESCRIPTION: At the Antibody Labeling Facility at the University of Nebraska Medical Center, the nuclear pharmacist provides support in the formulation, preparation, and quality testing of radiopharmaceuticals. The nuclear pharmacist also provides direct patient care by assisting in the administration of radiopharmaceuticals, monitoring patients during their infusions, and counseling patients on radioimmunotherapy and radiation safety. PRACTICE INNOVATION: Expanding the role of the nuclear pharmacist in treating patients with NHL using radiolabeled monoclonal antibodies (MABs). INTERVENTIONS: The nuclear pharmacist provides specialized pharmaceutical care by being involved in planning patient care, administering diagnostic and therapeutic radiopharmaceuticals, performing individualized patient dose calculations, monitoring patients, and counseling patients. MAIN OUTCOME MEASURES: Number of patients treated with radiolabeled MABs. RESULTS: Since January 1996, 85 patients with NHL have been treated using 131I-tositumomab (Corixa, GlaxoSmithKline), an anti-B1 MAB, under various clinical research protocols requiring specialized pharmaceutical care. The nuclear pharmacist on the team provided direct patient care, assisting with the administration of diagnostic and therapeutic radiopharmaceuticals under a collaborative agreement with a nuclear medicine physician or a radiation oncologist. Other pharmaceutical care activities performed include calculating individual patient doses, obtaining medication histories, counseling patients on their therapy and on radiation safety after early release, and monitoring patients for adverse effects during medication infusion. Patients have responded favorably to nontraditional nuclear pharmacy activities. CONCLUSION: The nuclear pharmacist has become an important member of the health care team that provides a new and unique therapy for patients with NHL. To date, the nuclear pharmacist, in collaboration with the nuclear medicine physician or the radiation oncologist, has successfully administered the tositumomab and 131I-tositumomab combination therapy without significant incident.",
author = "Augustine, {Samuel C.} and Norenberg, {Jeffrey P.} and Colcher, {David M.} and Vose, {Julie M.} and Gobar, {Lisa S.} and Dukat, {Valorie J.} and Hohenstein, {Maribeth A.} and Rutar, {Frank J.} and Jacobson, {David A.} and Tempero, {Margaret A.}",
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AU - Vose, Julie M.

AU - Gobar, Lisa S.

AU - Dukat, Valorie J.

AU - Hohenstein, Maribeth A.

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