Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds.

Bahram H. Arjmandi, Catherine D. Johnson, Sara C. Campbell, Shirin Hooshmand, Sheau C. Chai, Mohammed P. Akhter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Functional foods and/or their bioactive compounds playing a role in improving skeletal health have received considerable attention. The objective of the present study was to determine the extent to which certain functional foods as (1) whole, e.g., dried plum (DP), figs, dates, raisin, and blueberry, (2) fractionated, e.g., DP puree, DP juice, and DP pulp/skin, or (3) isolated, e.g., DP polyphenols, fructooligosaccharides (FOS), and beta-hydroxy-beta-methylbutyrate, forms reverse bone loss in an ovariectomized (Ovx) rat model of osteoporosis. Additionally, some of these components were tested in reversal of bone loss in combination. For this purpose, 180 3-month-old female Sprague-Dawley rats were divided into 15 groups (n = 12) and either Ovx (14 groups) or sham-operated (Sham, one group). Rats were maintained on a semipurified standard diet for 45 days after surgery to establish bone loss. Thereafter, rats were placed on one of the following dietary treatments for 60 days: casein-based diet (Sham and Ovx). The remaining 13 Ovx groups were placed on various treatment diets. Results showed that diets supplemented with 5% FOS + 7.5% DP was most effective in reversing both right femur and fourth lumbar bone mineral density and fourth lumbar calcium loss while significantly decreasing trabecular separation. There were no significant effects of treatment on serum or urine measures of bone turnover. Although other treatments were good at altering some bone parameters, none had the success in altering several bone health indicators as the diets supplemented with 5% FOS + 7.5% DP. The findings of this study suggest the combination of 5% FOS + 7.5% DP is capable of reversing Ovx-induced bone loss.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalJournal of Medicinal Food
Volume13
Issue number2
StatePublished - Apr 2010

Fingerprint

Functional Food
Bone Density
Bone and Bones
Diet
Blueberry Plants
Ficus
Prunus domestica
fructooligosaccharide
Bone Remodeling
Health
Vitis
Polyphenols
Caseins
Ambulatory Surgical Procedures
Femur
Osteoporosis
Sprague Dawley Rats
Urine
Calcium
Skin

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. / Arjmandi, Bahram H.; Johnson, Catherine D.; Campbell, Sara C.; Hooshmand, Shirin; Chai, Sheau C.; Akhter, Mohammed P.

In: Journal of Medicinal Food, Vol. 13, No. 2, 04.2010, p. 312-319.

Research output: Contribution to journalArticle

Arjmandi, Bahram H. ; Johnson, Catherine D. ; Campbell, Sara C. ; Hooshmand, Shirin ; Chai, Sheau C. ; Akhter, Mohammed P. / Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. In: Journal of Medicinal Food. 2010 ; Vol. 13, No. 2. pp. 312-319.
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