Comparative action of acetyl-beta-methylcholine, histamine, and pollen antigens in subjects with hay fever and patients with bronchial asthma

Robert G. Townley, Macey Dennis, Irving H. Itkin

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Eight of fourteen hay fever subjects had their first episode of wheezing following an aerosol inhalation of pollen extract. Sputum examinations confirmed the presence of many eosinophils within minutes after specific allergen challenge. The appearance of eosinophils in the sputum, the fall in FEV1, with cough, tightness, and wheezing, after specific allergen, and the subsequent response to bronchodilators indicate that these were indeed allergic changes simulating asthma in hay fever subjects. Eight hay fever subjects showed a significant decrease in FEV1 after Mecholyl and six after histamine inhalations. All of the twenty-five asthma patients tested and none of the nonatopic controls showed a significant decrease in FEV1 following Mecholyl and histamine challenge in the doses employed. In terms of bronchial sensitivity to the number of inhalations of the preparations used, the asthma patients were approximately twenty-seven times as sensitive to Mecholyl as the hay fever group, but only three and four times as sensitive to histamine and pollen inhalation, respectively. Antihistamines do not block or prevent induced bronchial obstruction in hay fever subjects and therefore should not be relied upon to prevent asthma. Finally, the method presented may be useful to determine which persons who have hay fever are later going to have asthma.

Original languageEnglish
Pages (from-to)121-137
Number of pages17
JournalJournal of Allergy
Volume36
Issue number2
StatePublished - Mar 1965
Externally publishedYes

Fingerprint

Seasonal Allergic Rhinitis
Methacholine Chloride
Pollen
Histamine
Asthma
Antigens
Inhalation
Respiratory Sounds
Sputum
Eosinophils
Allergens
Histamine Antagonists
Bronchodilator Agents
Aerosols
Cough

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Comparative action of acetyl-beta-methylcholine, histamine, and pollen antigens in subjects with hay fever and patients with bronchial asthma. / Townley, Robert G.; Dennis, Macey; Itkin, Irving H.

In: Journal of Allergy, Vol. 36, No. 2, 03.1965, p. 121-137.

Research output: Contribution to journalArticle

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