Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis

Yanfei L. Ma, Fernando Marin, Jan Stepan, Sophia Ish-Shalom, Rüdiger Möricke, Federico Hawkins, Georgios Kapetanos, María P. de la Peña, Jörn Kekow, Guillermo Martínez, Jorge Malouf, Qing Q. Zeng, Xiaohai Wan, Robert R. Recker

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Abstract

The periosteum contains osteogenic cells that regulate the outer shape of bone and contribute to determine its cortical thickness, size and position. We assessed the effects of subcutaneous injections of teriparatide (TPTD, 20μg/day) or oral strontium ranelate (SrR, 2g/day) in postmenopausal women with osteoporosis on new bone formation activity at the periosteal and endosteal bone surfaces using dynamic histomorphometric measurements. Evaluable tetracycline-labeled transiliac crest bone biopsies were analyzed from 27 patients in the TPTD group, and 22 in the SrR group after six months of treatment. Measurements were conducted on the thicker and thinner cortices separately, and comparisons between the thicker, thinner and combined cortices were carried out. At the combined periosteal cortex, the mineralization surface as a percent of bone surface (MS/BS%) was greater for TPTD (mean±SE: 8.08±1.22%) than SrR (3.22±1.05%) (p3/mm 2/year) and SrR (0.004plusmn;0.003 mm 3/mm 2/year) was not (p=0.057). Statistically significant differences between the two treatments were also observed for MS/BS%, BFR/BS, MAR and the double-labeled perimeter in the periosteum of the thicker, but not thinner, iliac crest cortices. The comparison between the thicker and thinner cortices of both periosteal and endosteal surfaces showed statistically significant differences for MAR and the double-labeled perimeter for TPTD treated women. There were no statistically significant differences in any bone formation dynamic measurements between the two cortices in the SrR group.In conclusion, most of the bone formation and mineralization variables were significantly higher for TPTD- than SrR-treated women at both the periosteal and endosteal combined cortices. The response to TPTD for dynamic bone formation measurements in the periosteal surface was greater for the thicker than thinner cortex, but this difference was not significant in SrR treated patients. This may reflect a greater ability of TPTD to enhance responsiveness of bone to the mechanical loading environment. These effects on bone formation may underlie the improvement in bone quality in patients with osteoporosis treated with TPTD.

Original languageEnglish
Pages (from-to)972-978
Number of pages7
JournalBone
Volume48
Issue number5
DOIs
StatePublished - May 1 2011

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strontium ranelate
Teriparatide
Periosteum
Osteoporosis
Osteogenesis
Biopsy
Bone and Bones
Physiologic Calcification
Subcutaneous Injections
Tetracycline

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis. / Ma, Yanfei L.; Marin, Fernando; Stepan, Jan; Ish-Shalom, Sophia; Möricke, Rüdiger; Hawkins, Federico; Kapetanos, Georgios; de la Peña, María P.; Kekow, Jörn; Martínez, Guillermo; Malouf, Jorge; Zeng, Qing Q.; Wan, Xiaohai; Recker, Robert R.

In: Bone, Vol. 48, No. 5, 01.05.2011, p. 972-978.

Research output: Contribution to journalArticle

Ma, YL, Marin, F, Stepan, J, Ish-Shalom, S, Möricke, R, Hawkins, F, Kapetanos, G, de la Peña, MP, Kekow, J, Martínez, G, Malouf, J, Zeng, QQ, Wan, X & Recker, RR 2011, 'Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis', Bone, vol. 48, no. 5, pp. 972-978. https://doi.org/10.1016/j.bone.2011.01.012
Ma, Yanfei L. ; Marin, Fernando ; Stepan, Jan ; Ish-Shalom, Sophia ; Möricke, Rüdiger ; Hawkins, Federico ; Kapetanos, Georgios ; de la Peña, María P. ; Kekow, Jörn ; Martínez, Guillermo ; Malouf, Jorge ; Zeng, Qing Q. ; Wan, Xiaohai ; Recker, Robert R. / Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis. In: Bone. 2011 ; Vol. 48, No. 5. pp. 972-978.
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abstract = "The periosteum contains osteogenic cells that regulate the outer shape of bone and contribute to determine its cortical thickness, size and position. We assessed the effects of subcutaneous injections of teriparatide (TPTD, 20μg/day) or oral strontium ranelate (SrR, 2g/day) in postmenopausal women with osteoporosis on new bone formation activity at the periosteal and endosteal bone surfaces using dynamic histomorphometric measurements. Evaluable tetracycline-labeled transiliac crest bone biopsies were analyzed from 27 patients in the TPTD group, and 22 in the SrR group after six months of treatment. Measurements were conducted on the thicker and thinner cortices separately, and comparisons between the thicker, thinner and combined cortices were carried out. At the combined periosteal cortex, the mineralization surface as a percent of bone surface (MS/BS{\%}) was greater for TPTD (mean±SE: 8.08±1.22{\%}) than SrR (3.22±1.05{\%}) (p3/mm 2/year) and SrR (0.004plusmn;0.003 mm 3/mm 2/year) was not (p=0.057). Statistically significant differences between the two treatments were also observed for MS/BS{\%}, BFR/BS, MAR and the double-labeled perimeter in the periosteum of the thicker, but not thinner, iliac crest cortices. The comparison between the thicker and thinner cortices of both periosteal and endosteal surfaces showed statistically significant differences for MAR and the double-labeled perimeter for TPTD treated women. There were no statistically significant differences in any bone formation dynamic measurements between the two cortices in the SrR group.In conclusion, most of the bone formation and mineralization variables were significantly higher for TPTD- than SrR-treated women at both the periosteal and endosteal combined cortices. The response to TPTD for dynamic bone formation measurements in the periosteal surface was greater for the thicker than thinner cortex, but this difference was not significant in SrR treated patients. This may reflect a greater ability of TPTD to enhance responsiveness of bone to the mechanical loading environment. These effects on bone formation may underlie the improvement in bone quality in patients with osteoporosis treated with TPTD.",
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AU - Ma, Yanfei L.

AU - Marin, Fernando

AU - Stepan, Jan

AU - Ish-Shalom, Sophia

AU - Möricke, Rüdiger

AU - Hawkins, Federico

AU - Kapetanos, Georgios

AU - de la Peña, María P.

AU - Kekow, Jörn

AU - Martínez, Guillermo

AU - Malouf, Jorge

AU - Zeng, Qing Q.

AU - Wan, Xiaohai

AU - Recker, Robert R.

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N2 - The periosteum contains osteogenic cells that regulate the outer shape of bone and contribute to determine its cortical thickness, size and position. We assessed the effects of subcutaneous injections of teriparatide (TPTD, 20μg/day) or oral strontium ranelate (SrR, 2g/day) in postmenopausal women with osteoporosis on new bone formation activity at the periosteal and endosteal bone surfaces using dynamic histomorphometric measurements. Evaluable tetracycline-labeled transiliac crest bone biopsies were analyzed from 27 patients in the TPTD group, and 22 in the SrR group after six months of treatment. Measurements were conducted on the thicker and thinner cortices separately, and comparisons between the thicker, thinner and combined cortices were carried out. At the combined periosteal cortex, the mineralization surface as a percent of bone surface (MS/BS%) was greater for TPTD (mean±SE: 8.08±1.22%) than SrR (3.22±1.05%) (p3/mm 2/year) and SrR (0.004plusmn;0.003 mm 3/mm 2/year) was not (p=0.057). Statistically significant differences between the two treatments were also observed for MS/BS%, BFR/BS, MAR and the double-labeled perimeter in the periosteum of the thicker, but not thinner, iliac crest cortices. The comparison between the thicker and thinner cortices of both periosteal and endosteal surfaces showed statistically significant differences for MAR and the double-labeled perimeter for TPTD treated women. There were no statistically significant differences in any bone formation dynamic measurements between the two cortices in the SrR group.In conclusion, most of the bone formation and mineralization variables were significantly higher for TPTD- than SrR-treated women at both the periosteal and endosteal combined cortices. The response to TPTD for dynamic bone formation measurements in the periosteal surface was greater for the thicker than thinner cortex, but this difference was not significant in SrR treated patients. This may reflect a greater ability of TPTD to enhance responsiveness of bone to the mechanical loading environment. These effects on bone formation may underlie the improvement in bone quality in patients with osteoporosis treated with TPTD.

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