Comparison of indocyanine green clearance with Child's-Pugh score and hepatic histology

A multivariate analysis

Sandeep Mukherjee, Mary A M Rogers, Borys Buniak

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: Indocyanine green clearance, measured by percentage disappearance rate, detects alterations in liver function and may be used as a non-invasive determinant of hepatic reserve. The aims of this study were to compare liver histology and Child's-Pugh score with percentage disappearance rate and determine which variables correlated with PDR. Methodology: Child's-Pugh score, liver function tests, liver biopsies and indocyanine green testing (0.5mg/kg) were performed in 102 consecutive patients with cirrhosis of diverse etiologies. Indocyanine green concentration was determined using spectrophotometric analysis (806nm) and plotted logarithmically with Michaelis-Menten kinetics to calculate the percentage disappearance rate. Liver biopsies were graded using the modified Knodell score to obtain a histological activity index. Results: In bivariable analysis, percentage disappearance rate significantly correlated with Child's-Pugh score, albumin, bilirubin, prothrombin time and histological activity index. Albumin, prothrombin time and histological activity index were independent predictors of percentage disappearance rate in the final model (albumin p

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalHepato-Gastroenterology
Volume53
Issue number67
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Indocyanine Green
Histology
Multivariate Analysis
Liver
Albumins
Prothrombin Time
Biopsy
Liver Function Tests
Bilirubin
Fibrosis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Comparison of indocyanine green clearance with Child's-Pugh score and hepatic histology : A multivariate analysis. / Mukherjee, Sandeep; Rogers, Mary A M; Buniak, Borys.

In: Hepato-Gastroenterology, Vol. 53, No. 67, 01.2006, p. 120-123.

Research output: Contribution to journalArticle

@article{a60b6ad8e8774b4aa81760e4d6d2197b,
title = "Comparison of indocyanine green clearance with Child's-Pugh score and hepatic histology: A multivariate analysis",
abstract = "Background/Aims: Indocyanine green clearance, measured by percentage disappearance rate, detects alterations in liver function and may be used as a non-invasive determinant of hepatic reserve. The aims of this study were to compare liver histology and Child's-Pugh score with percentage disappearance rate and determine which variables correlated with PDR. Methodology: Child's-Pugh score, liver function tests, liver biopsies and indocyanine green testing (0.5mg/kg) were performed in 102 consecutive patients with cirrhosis of diverse etiologies. Indocyanine green concentration was determined using spectrophotometric analysis (806nm) and plotted logarithmically with Michaelis-Menten kinetics to calculate the percentage disappearance rate. Liver biopsies were graded using the modified Knodell score to obtain a histological activity index. Results: In bivariable analysis, percentage disappearance rate significantly correlated with Child's-Pugh score, albumin, bilirubin, prothrombin time and histological activity index. Albumin, prothrombin time and histological activity index were independent predictors of percentage disappearance rate in the final model (albumin p",
author = "Sandeep Mukherjee and Rogers, {Mary A M} and Borys Buniak",
year = "2006",
month = "1",
language = "English",
volume = "53",
pages = "120--123",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "67",

}

TY - JOUR

T1 - Comparison of indocyanine green clearance with Child's-Pugh score and hepatic histology

T2 - A multivariate analysis

AU - Mukherjee, Sandeep

AU - Rogers, Mary A M

AU - Buniak, Borys

PY - 2006/1

Y1 - 2006/1

N2 - Background/Aims: Indocyanine green clearance, measured by percentage disappearance rate, detects alterations in liver function and may be used as a non-invasive determinant of hepatic reserve. The aims of this study were to compare liver histology and Child's-Pugh score with percentage disappearance rate and determine which variables correlated with PDR. Methodology: Child's-Pugh score, liver function tests, liver biopsies and indocyanine green testing (0.5mg/kg) were performed in 102 consecutive patients with cirrhosis of diverse etiologies. Indocyanine green concentration was determined using spectrophotometric analysis (806nm) and plotted logarithmically with Michaelis-Menten kinetics to calculate the percentage disappearance rate. Liver biopsies were graded using the modified Knodell score to obtain a histological activity index. Results: In bivariable analysis, percentage disappearance rate significantly correlated with Child's-Pugh score, albumin, bilirubin, prothrombin time and histological activity index. Albumin, prothrombin time and histological activity index were independent predictors of percentage disappearance rate in the final model (albumin p

AB - Background/Aims: Indocyanine green clearance, measured by percentage disappearance rate, detects alterations in liver function and may be used as a non-invasive determinant of hepatic reserve. The aims of this study were to compare liver histology and Child's-Pugh score with percentage disappearance rate and determine which variables correlated with PDR. Methodology: Child's-Pugh score, liver function tests, liver biopsies and indocyanine green testing (0.5mg/kg) were performed in 102 consecutive patients with cirrhosis of diverse etiologies. Indocyanine green concentration was determined using spectrophotometric analysis (806nm) and plotted logarithmically with Michaelis-Menten kinetics to calculate the percentage disappearance rate. Liver biopsies were graded using the modified Knodell score to obtain a histological activity index. Results: In bivariable analysis, percentage disappearance rate significantly correlated with Child's-Pugh score, albumin, bilirubin, prothrombin time and histological activity index. Albumin, prothrombin time and histological activity index were independent predictors of percentage disappearance rate in the final model (albumin p

UR - http://www.scopus.com/inward/record.url?scp=33344457832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33344457832&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 120

EP - 123

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 67

ER -