Comparison of indocyanine green clearance with Child's-Pugh score and hepatic histology: A multivariate analysis

Sandeep Mukherjee, Mary A M Rogers, Borys Buniak

Research output: Contribution to journalArticle

8 Scopus citations


Background/Aims: Indocyanine green clearance, measured by percentage disappearance rate, detects alterations in liver function and may be used as a non-invasive determinant of hepatic reserve. The aims of this study were to compare liver histology and Child's-Pugh score with percentage disappearance rate and determine which variables correlated with PDR. Methodology: Child's-Pugh score, liver function tests, liver biopsies and indocyanine green testing (0.5mg/kg) were performed in 102 consecutive patients with cirrhosis of diverse etiologies. Indocyanine green concentration was determined using spectrophotometric analysis (806nm) and plotted logarithmically with Michaelis-Menten kinetics to calculate the percentage disappearance rate. Liver biopsies were graded using the modified Knodell score to obtain a histological activity index. Results: In bivariable analysis, percentage disappearance rate significantly correlated with Child's-Pugh score, albumin, bilirubin, prothrombin time and histological activity index. Albumin, prothrombin time and histological activity index were independent predictors of percentage disappearance rate in the final model (albumin p

Original languageEnglish
Pages (from-to)120-123
Number of pages4
Issue number67
Publication statusPublished - Jan 2006
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Gastroenterology

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