Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects

U. Y. Ryo, R. G. Townley

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.

Original languageEnglish
Pages (from-to)12-24
Number of pages13
JournalJournal of Allergy and Clinical Immunology
Volume57
Issue number1
DOIs
StatePublished - 1976

Fingerprint

Practolol
Methacholine Chloride
Isoproterenol
Propranolol
Lung
Airway Resistance
Pulse
Electrocardiography
Asthma
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects. / Ryo, U. Y.; Townley, R. G.

In: Journal of Allergy and Clinical Immunology, Vol. 57, No. 1, 1976, p. 12-24.

Research output: Contribution to journalArticle

@article{e999b58eedc24a5eba61f86f98ab3eb0,
title = "Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects",
abstract = "Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.",
author = "Ryo, {U. Y.} and Townley, {R. G.}",
year = "1976",
doi = "10.1016/0091-6749(76)90074-9",
language = "English",
volume = "57",
pages = "12--24",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects

AU - Ryo, U. Y.

AU - Townley, R. G.

PY - 1976

Y1 - 1976

N2 - Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.

AB - Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.

UR - http://www.scopus.com/inward/record.url?scp=0017295563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017295563&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(76)90074-9

DO - 10.1016/0091-6749(76)90074-9

M3 - Article

VL - 57

SP - 12

EP - 24

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 1

ER -