Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects

U. Y. Ryo, R. G. Townley

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.

Original languageEnglish (US)
Pages (from-to)12-24
Number of pages13
JournalThe Journal of Allergy and Clinical Immunology
Volume57
Issue number1
DOIs
StatePublished - Jan 1976

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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