TY - JOUR
T1 - Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects
AU - Ryo, U. Y.
AU - Townley, R. G.
N1 - Funding Information:
From thP Department of Medicine, Creighton University School of Medicine. Supported in part by the Ayerst Pharmaceutical Company. Received for publication Aug. 12, 1974. Accepted for publication Dec. 16, 1974. Reprint requests to: Robert G. Totvnley, M.D., Department of Medicine and Microbiology, Criss I, Room 408, Creightou University School of Medicine, 2500 California St., Omaha, Nebr. 68178.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1976/1
Y1 - 1976/1
N2 - Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.
AB - Pulmonary functions, by means of FEV1, FVC, and airway resistance, and cardiovascular responses, i.e., ECG, blood pressure, and pulse contour, were measured in 10 control and 15 symptom-free asthmatic subjects during and after the infusions of isoproterenol, with or without previous administration of propranolol or practolol. Bronchial sensitivity to methacholine and response to isoproterenol after methacholine were also measured. Bronchial sensitivity to methacholine challenge was markedly enhanced by propranolol and the effect of isoproterenol infusion on the pulmonary function was also significantly diminished, whereas practolol did not reveal any effect on bronchial sensitivity to methacholine or isoproterenol. The above changes were much more profound in symptom-free asthmatic subjects than in control subjects. The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in bronchial asthma.
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U2 - 10.1016/0091-6749(76)90074-9
DO - 10.1016/0091-6749(76)90074-9
M3 - Article
C2 - 1245680
AN - SCOPUS:0017295563
VL - 57
SP - 12
EP - 24
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 1
ER -