Comparison of transmitted pressure across percutaneous abdominal aorta aneurysm conduits: A new in vitro model

P. E. Thorpe, D. W. Hunter, P. Chouinard, Devendra K. Agrawal, X. X. Zhan

Research output: Contribution to journalArticle

Abstract

The treatment of abdominal aorta aneurysm is aimed at decreasing pressure on the arterial wall which is thought to cause growth and eventual rupture of the aneurysm. If significant pressure is transmitted across percutaneously placed stem-grafts, they may prove unacceptable for abdominal aorta aneurysm repair. Therefore, we developed an in mm model to study transmission of pressure across various materials implanted in an aneurysmal lumen. A pinch roller model producing pulsatile flow through an aneurysm fashioned from heated polyethylene was used with H2O, glycerol and heparinized bovine blood. Continuous pressure readings obtained from 3 sites (above, below and mid aneurysm) were compared between different materials including bare metal stent, dacron. polytetrafluoroethylene (PTFE) graft, graft plus stent and silicone covered metal stent. Bare metal is less effective than dacron or PTFE graft in reducing the systolic/diastolic gradient. Transmitted pressure amplitude is further diminished by combining graft material with a metal stent. This model is effective for measuring pressure transmitted through an artificial conduit. This model may be modified to simulate the combined effect of extraluminal pressure plus persistent lumbar flow to further study abdominal aorta aneurysm stent graft procedures and ideal stent/graft properties.

Original languageEnglish
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

aneurysm
Abdominal Aorta
Stents
aorta
Grafts
Aneurysm
Transplants
Pressure
Metals
metals
Polyethylene Terephthalates
Polytetrafluoroethylene
Pulsatile Flow
Pulsatile flow
silicone
Polyethylene
Silicones
In Vitro Techniques
polyethylene
Glycerol

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Comparison of transmitted pressure across percutaneous abdominal aorta aneurysm conduits : A new in vitro model. / Thorpe, P. E.; Hunter, D. W.; Chouinard, P.; Agrawal, Devendra K.; Zhan, X. X.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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