Complete Asymmetric Induction in Synthesis of Enantiomerically Pure Steroid Intermediates of Natural Configuration

Gary H. Posner, Martin Hulee, John P. Mallamo, Steven A. Drexler, Jon Clardy

Research output: Contribution to journalLetter

37 Scopus citations

Abstract

Enantiomerically pure steroid intermediates (S)-1 and (S)-(+)-2 of natural absolute configuration have been prepared with complete asymmetric induction during zinc dibromide mediated vinylmagnesium bromide conjugate addition to enantiomerically pure, crystalline, stable cyclopentenone sulfoxide (S)-(+)-5, which has been prepared on a 10-g scale.

Original languageEnglish (US)
Pages (from-to)5244-5246
Number of pages3
JournalJournal of Organic Chemistry
Volume46
Issue number25
DOIs
StatePublished - Dec 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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