Complete Transposition of Great Vessels

Manifestation in Two Siblings Confirmed at Autopsy

Henry T. Lynch, R. L. Grissom, P. Mooring, A. Krush

Research output: Contribution to journalArticle

Abstract

A family has been studied wherein two siblings manifested complete transposition of the great vessels, confirmed at autopsy. Consanguinity was absent and no toxic exposure was found during the prenatal period in either case. All available family members were studied and found to be normal. Only one previous report of this cardiac anomaly in siblings has been found; however, there have been several reports showing complete transposition of the great vessels in one sibling, while another sibling manifested cardiac defects within the spectrum of truncoconal malformations. A genetic fault is postulated as the etiology of some truncoconal malformations, in which a gene effect during embryogenesis, in concert with the intrauterine milieu, produces various anomalies.

Original languageEnglish
Pages (from-to)969-972
Number of pages4
JournalJAMA - Journal of the American Medical Association
Volume190
Issue number11
DOIs
StatePublished - Dec 14 1964
Externally publishedYes

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Transposition of Great Vessels
Siblings
Autopsy
Consanguinity
Poisons
Embryonic Development
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Complete Transposition of Great Vessels : Manifestation in Two Siblings Confirmed at Autopsy. / Lynch, Henry T.; Grissom, R. L.; Mooring, P.; Krush, A.

In: JAMA - Journal of the American Medical Association, Vol. 190, No. 11, 14.12.1964, p. 969-972.

Research output: Contribution to journalArticle

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