A family has been studied wherein two siblings manifested complete transposition of the great vessels, confirmed at autopsy. Consanguinity was absent and no toxic exposure was found during the prenatal period in either case. All available family members were studied and found to be normal. Only one previous report of this cardiac anomaly in siblings has been found; however, there have been several reports showing complete transposition of the great vessels in one sibling, while another sibling manifested cardiac defects within the spectrum of truncoconal malformations. A genetic fault is postulated as the etiology of some truncoconal malformations, in which a gene effect during embryogenesis, in concert with the intrauterine milieu, produces various anomalies.
|Original language||English (US)|
|Number of pages||4|
|Journal||JAMA: The Journal of the American Medical Association|
|State||Published - Dec 14 1964|
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