Comprehensive analysis of the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with BMD in Caucasian women

Qiu Hong Zhou, Lan Juan Zhao, Ping Wang, Rhamee Badr, Xiao Jing Xu, Feng Xiao Bu, Joan M. Lappe, Robert R. Recker, Yu Zhou, An Ye, Bo Ting Zhou

Research output: Contribution to journalArticle

Abstract

Summary: Three genes, including EGFR (epidermal growth factor receptor), CALM3 (calmodulin 3, calcium-modulated protein 3) and SMARCD1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily d member 1), play different roles in bone and/or fat metabolism in Caucasian women. In this population-based investigation of 870 unrelated postmenopausal Caucasian women, CALM3 polymorphisms were significantly associated with femoral neck bone mineral density (FNK BMD), hip BMD and spine BMD. Age and tobacco status also affected BMD levels and were therefore corrected for in our statistical analysis. Introduction: EGFR, CALM3 and SMARCD1 play roles in bone and/or fat metabolism. However, the correlations between the polymorphisms of these three genes and body composition levels, including BMD, remain to be determined. Materials and Methods: A population-based investigation of 870 white women was conducted. Forty-four SNPs (single nucleotide polymorphisms) in EGFR, CALM3 and SMARCD1 were chosen by the software, including those of potential functional importance. The candidate SNPs were genotyped by the KASPar assay for an association analysis with body composition levels. The correlation analysis was assessed by the Pearson's product-moment correlation coefficient and Spearman rank-order correlation tests, and the family-wise error was corrected using the Wald test implemented in PLINK. Results: The SNP rs12461917 in the 3′-flanking region of the CALM3 gene was significantly associated with FNK BMD (P = 0.001), hip BMD (P

Original languageEnglish
Article numbere112358
JournalPLoS One
Volume9
Issue number11
DOIs
StatePublished - Nov 14 2014

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calmodulin
Calmodulin
Polymorphism
Epidermal Growth Factor Receptor
Chromatin
actin
chromatin
Actins
Genes
Association reactions
genetic polymorphism
Calcium
calcium
Bone
single nucleotide polymorphism
Single Nucleotide Polymorphism
Proteins
genes
Nucleotides
proteins

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zhou, Q. H., Zhao, L. J., Wang, P., Badr, R., Xu, X. J., Bu, F. X., ... Zhou, B. T. (2014). Comprehensive analysis of the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with BMD in Caucasian women. PLoS One, 9(11), [e112358]. https://doi.org/10.1371/journal.pone.0112358

Comprehensive analysis of the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with BMD in Caucasian women. / Zhou, Qiu Hong; Zhao, Lan Juan; Wang, Ping; Badr, Rhamee; Xu, Xiao Jing; Bu, Feng Xiao; Lappe, Joan M.; Recker, Robert R.; Zhou, Yu; Ye, An; Zhou, Bo Ting.

In: PLoS One, Vol. 9, No. 11, e112358, 14.11.2014.

Research output: Contribution to journalArticle

Zhou, Qiu Hong ; Zhao, Lan Juan ; Wang, Ping ; Badr, Rhamee ; Xu, Xiao Jing ; Bu, Feng Xiao ; Lappe, Joan M. ; Recker, Robert R. ; Zhou, Yu ; Ye, An ; Zhou, Bo Ting. / Comprehensive analysis of the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with BMD in Caucasian women. In: PLoS One. 2014 ; Vol. 9, No. 11.
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