Connectivity and convergence of single corticostriatal axons

Anthony E. Kincaid, Tong Zheng, Charles J. Wilson

Research output: Contribution to journalArticle

191 Scopus citations

Abstract

The distribution of synapses formed by corticostriatal neurons was measured to determine the average connectivity and degree of convergence of these neurons and to search for spatial inhomogeneities. Two kinds of axonal fields, focal and extended, and two striatal tissue compartments, the patch (striosome) and matrix, were analyzed separately. Electron microscopic examination revealed that both kinds of corticostriatal axons made synapses at varicosities that could be identified in the light microscope, and each varicosity made a single synapse. Thus, the distribution of varicosities was a good estimate of the spatial distribution of synapses. The distance between axonal varicosities was measured to determine the density of synaptic connections formed by one axon within the volume occupied by a striatal neuron. Intersynaptic distances were distributed exponentially, except that synapses were rarely located

Original languageEnglish (US)
Pages (from-to)4722-4731
Number of pages10
JournalJournal of Neuroscience
Volume18
Issue number12
DOIs
StatePublished - Jun 15 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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