Abstract
The distribution of synapses formed by corticostriatal neurons was measured to determine the average connectivity and degree of convergence of these neurons and to search for spatial inhomogeneities. Two kinds of axonal fields, focal and extended, and two striatal tissue compartments, the patch (striosome) and matrix, were analyzed separately. Electron microscopic examination revealed that both kinds of corticostriatal axons made synapses at varicosities that could be identified in the light microscope, and each varicosity made a single synapse. Thus, the distribution of varicosities was a good estimate of the spatial distribution of synapses. The distance between axonal varicosities was measured to determine the density of synaptic connections formed by one axon within the volume occupied by a striatal neuron. Intersynaptic distances were distributed exponentially, except that synapses were rarely located
| Original language | English |
|---|---|
| Pages (from-to) | 4722-4731 |
| Number of pages | 10 |
| Journal | Journal of Neuroscience |
| Volume | 18 |
| Issue number | 12 |
| State | Published - Jun 15 1998 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
Connectivity and convergence of single corticostriatal axons. / Kincaid, Anthony; Zheng, Tong; Wilson, Charles J.
In: Journal of Neuroscience, Vol. 18, No. 12, 15.06.1998, p. 4722-4731.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Connectivity and convergence of single corticostriatal axons
AU - Kincaid, Anthony
AU - Zheng, Tong
AU - Wilson, Charles J.
PY - 1998/6/15
Y1 - 1998/6/15
N2 - The distribution of synapses formed by corticostriatal neurons was measured to determine the average connectivity and degree of convergence of these neurons and to search for spatial inhomogeneities. Two kinds of axonal fields, focal and extended, and two striatal tissue compartments, the patch (striosome) and matrix, were analyzed separately. Electron microscopic examination revealed that both kinds of corticostriatal axons made synapses at varicosities that could be identified in the light microscope, and each varicosity made a single synapse. Thus, the distribution of varicosities was a good estimate of the spatial distribution of synapses. The distance between axonal varicosities was measured to determine the density of synaptic connections formed by one axon within the volume occupied by a striatal neuron. Intersynaptic distances were distributed exponentially, except that synapses were rarely located
AB - The distribution of synapses formed by corticostriatal neurons was measured to determine the average connectivity and degree of convergence of these neurons and to search for spatial inhomogeneities. Two kinds of axonal fields, focal and extended, and two striatal tissue compartments, the patch (striosome) and matrix, were analyzed separately. Electron microscopic examination revealed that both kinds of corticostriatal axons made synapses at varicosities that could be identified in the light microscope, and each varicosity made a single synapse. Thus, the distribution of varicosities was a good estimate of the spatial distribution of synapses. The distance between axonal varicosities was measured to determine the density of synaptic connections formed by one axon within the volume occupied by a striatal neuron. Intersynaptic distances were distributed exponentially, except that synapses were rarely located
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UR - http://www.scopus.com/inward/citedby.url?scp=0032526982&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 4722
EP - 4731
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 12
ER -