Continued expansion of USA300-like methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in the United States

Isabella A. Tickler, Richard V. Goering, Jose R. Mediavilla, Barry N. Kreiswirth, Fred C. Tenover

Research output: Research - peer-reviewArticle

Abstract

We characterized spa types, SCC. mec types, and antimicrobial resistance patterns of 516 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between 2011 and 2014 from nares and blood cultures of United States patients. Among nares isolates, 45 spa types were observed; 29.9% were t002/SCC. mec II and 30.9% were t008/SCC. mec IV. Among blood isolates, 40 spa types were identified; 24.4% were t002/SCC. mec II and 39.9% were type t008/SCC. mec IV. Compared to data from our 2009-2010 survey, the percentage of t008/SCC. mec IV isolates from nares increased significantly (20.4%-30.9%; P = 0.004) while the percentage from positive blood cultures remained similar (39.2% versus 39.9%; P = 0.921). There were also significant changes in the overall antimicrobial resistance patterns observed, including the decrease of the clindamycin, erythromycin, levofloxacin and moxifloxacin multidrug resistance pattern, likely the result of t002/SCC. mec II strains being displaced by t008/SCC. mec IV strains. Rates of high-level mupirocin resistance did not change significantly from our past study (4.1% compared to 4.7%; P = 0.758) but an increase in low-level resistance, particularly among t002/SCC. mec II isolates, was observed.

LanguageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Feb 1 2017

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Methicillin-Resistant Staphylococcus aureus
Blood Culture
Mupirocin
Levofloxacin
Clindamycin
Multiple Drug Resistance
Erythromycin
moxifloxacin
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Continued expansion of USA300-like methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in the United States. / Tickler, Isabella A.; Goering, Richard V.; Mediavilla, Jose R.; Kreiswirth, Barry N.; Tenover, Fred C.

In: Diagnostic Microbiology and Infectious Disease, 01.02.2017.

Research output: Research - peer-reviewArticle

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