Continuous infusion of naloxone in the treatment of narcotic overdose

J. Chris Bradberry, Marsha A. Raebel

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


This paper describes case reports and pharmacokinetic information regarding the continuous intravenous administration of naloxone in treatment of narcotic overdose. Continuous naloxone infusion has been used successfully in acutely narcotized patients, and a review of the pharmacodynamic and pharmacokinetic properties of naloxone indicate the reasons for this mode of administration. Summaries of clinical studies in support of the infusion method are given. A naloxone protocol is outlined.

Original languageEnglish
Pages (from-to)945-950
Number of pages6
JournalAnnals of Pharmacotherapy
Issue number12
StatePublished - 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)


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