Continuous infusion of naloxone in the treatment of narcotic overdose

J. Chris Bradberry; Marsha A. Raebel

doi:10.1177/106002808101501205

Continuous infusion of naloxone in the treatment of narcotic overdose

J. Chris Bradberry, Marsha A. Raebel

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

This paper describes case reports and pharmacokinetic information regarding the continuous intravenous administration of naloxone in treatment of narcotic overdose. Continuous naloxone infusion has been used successfully in acutely narcotized patients, and a review of the pharmacodynamic and pharmacokinetic properties of naloxone indicate the reasons for this mode of administration. Summaries of clinical studies in support of the infusion method are given. A naloxone protocol is outlined.

Original language	English
Pages (from-to)	945-950
Number of pages	6
Journal	Annals of Pharmacotherapy
Volume	15
Issue number	12
DOIs	https://doi.org/10.1177/106002808101501205
State	Published - 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

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abstract = "This paper describes case reports and pharmacokinetic information regarding the continuous intravenous administration of naloxone in treatment of narcotic overdose. Continuous naloxone infusion has been used successfully in acutely narcotized patients, and a review of the pharmacodynamic and pharmacokinetic properties of naloxone indicate the reasons for this mode of administration. Summaries of clinical studies in support of the infusion method are given. A naloxone protocol is outlined.",

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