Contraction and relaxation of rabbit basilar artery by thiopental

C. E. Gross; P. W. Abel

doi:10.1227/00006123-198509000-00006

Contraction and relaxation of rabbit basilar artery by thiopental

C. E. Gross, P. W. Abel

Department of Pharmacology and Neuroscience

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10^-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10^-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10^-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.

Original language	English (US)
Pages (from-to)	433-435
Number of pages	3
Journal	Neurosurgery
Volume	17
Issue number	3
DOIs	https://doi.org/10.1227/00006123-198509000-00006
State	Published - 1985

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology

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abstract = "Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.",

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AB - Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.

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