Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.
All Science Journal Classification (ASJC) codes
- Clinical Neurology