Abstract
Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.
Original language | English (US) |
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Pages (from-to) | 433-435 |
Number of pages | 3 |
Journal | Neurosurgery |
Volume | 17 |
Issue number | 3 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology