Contraction and relaxation of rabbit basilar artery by thiopental

C. E. Gross, P. W. Abel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 x 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 x 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 x 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalNeurosurgery
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1985

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this