Abstract
Background: Ethnicity is shown to be one of important factors affecting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods: The studied restriction fragment length polymorphisms were BsaH I of the calcium-sensing receptor gene, Sac I of the α2 HS-glycoprotein (AHSG) gene, Pvu II and Xba I of the oestrogen receptor α gene, Apa I of the vitamin D receptor (VDR) gene and BstB I of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results: Two polymorphisms, AHSG-Sac I and VDR-Apa I, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion: The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.
| Original language | English |
|---|---|
| Pages (from-to) | 1235-1244 |
| Number of pages | 10 |
| Journal | Chinese Medical Journal |
| Volume | 118 |
| Issue number | 15 |
| State | Published - Aug 5 2005 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese : A test for five candidate genes for bone mass. / Dvornyk, Volodymyr; Liu, Peng Yuan; Long, Ji Rong; Zhang, Yuan Yuan; Lei, Shu Feng; Recker, Robert R.; Deng, Hong Wen.
In: Chinese Medical Journal, Vol. 118, No. 15, 05.08.2005, p. 1235-1244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese
T2 - A test for five candidate genes for bone mass
AU - Dvornyk, Volodymyr
AU - Liu, Peng Yuan
AU - Long, Ji Rong
AU - Zhang, Yuan Yuan
AU - Lei, Shu Feng
AU - Recker, Robert R.
AU - Deng, Hong Wen
PY - 2005/8/5
Y1 - 2005/8/5
N2 - Background: Ethnicity is shown to be one of important factors affecting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods: The studied restriction fragment length polymorphisms were BsaH I of the calcium-sensing receptor gene, Sac I of the α2 HS-glycoprotein (AHSG) gene, Pvu II and Xba I of the oestrogen receptor α gene, Apa I of the vitamin D receptor (VDR) gene and BstB I of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results: Two polymorphisms, AHSG-Sac I and VDR-Apa I, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion: The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.
AB - Background: Ethnicity is shown to be one of important factors affecting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods: The studied restriction fragment length polymorphisms were BsaH I of the calcium-sensing receptor gene, Sac I of the α2 HS-glycoprotein (AHSG) gene, Pvu II and Xba I of the oestrogen receptor α gene, Apa I of the vitamin D receptor (VDR) gene and BstB I of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results: Two polymorphisms, AHSG-Sac I and VDR-Apa I, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion: The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.
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M3 - Article
VL - 118
SP - 1235
EP - 1244
JO - Chinese Medical Journal
JF - Chinese Medical Journal
SN - 0366-6999
IS - 15
ER -