TY - JOUR
T1 - Controlled release of a model protein lysozyme from phase sensitive smart polymer systems
AU - Singh, Somnath
AU - Singh, Jagdish
PY - 2004/3/1
Y1 - 2004/3/1
N2 - The purpose of this study was to investigate the suitability of phase sensitive smart polymer-based protein formulations in order to deliver a model protein, lysozyme, in a conformationally stable and biologically active form at a controlled rate over extended period of time. Four different formulations, using D,L-poly(lactide) (D,L-PLA) and a solvent mixture of different ratios of benzyl benzoate (BB) and benzyl alcohol (BA), were prepared. Conformational stability and biological activity of lysozyme were studied by differential scanning calorimeter and enzyme activity assay, respectively. We found a significant (P
AB - The purpose of this study was to investigate the suitability of phase sensitive smart polymer-based protein formulations in order to deliver a model protein, lysozyme, in a conformationally stable and biologically active form at a controlled rate over extended period of time. Four different formulations, using D,L-poly(lactide) (D,L-PLA) and a solvent mixture of different ratios of benzyl benzoate (BB) and benzyl alcohol (BA), were prepared. Conformational stability and biological activity of lysozyme were studied by differential scanning calorimeter and enzyme activity assay, respectively. We found a significant (P
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U2 - 10.1016/j.ijpharm.2003.11.010
DO - 10.1016/j.ijpharm.2003.11.010
M3 - Article
C2 - 15129985
AN - SCOPUS:1142285516
VL - 271
SP - 189
EP - 196
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -