Controlled release of a model protein lysozyme from phase sensitive smart polymer systems

Somnath Singh, Jagdish Singh

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The purpose of this study was to investigate the suitability of phase sensitive smart polymer-based protein formulations in order to deliver a model protein, lysozyme, in a conformationally stable and biologically active form at a controlled rate over extended period of time. Four different formulations, using D,L-poly(lactide) (D,L-PLA) and a solvent mixture of different ratios of benzyl benzoate (BB) and benzyl alcohol (BA), were prepared. Conformational stability and biological activity of lysozyme were studied by differential scanning calorimeter and enzyme activity assay, respectively. We found a significant (P

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume271
Issue number1-2
DOIs
StatePublished - Mar 1 2004

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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