Coronary artery bypass graft

Why is the saphenous vein prone to intimal hyperplasia?1

Swastika Sur, Jeffrey T. Sugimoto, Devendra K. Agrawal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Proliferation and migration of smooth muscle cells and the resultant intimal hyperplasia cause coronary artery bypass graft failure. Both internal mammary artery and saphenous vein are the most commonly used bypass conduits. Although an internal mammary artery graft is immune to restenosis, a saphenous vein graft is prone to develop restenosis. We found significantly higher activity of phosphatase and tensin homolog (PTEN) in the smooth muscle cells of the internal mammary artery than in the saphenous vein. In this article, we critically review the pathophysiology of vein-graft failure with detailed discussion of the involvement of various factors, including PTEN, matrix metalloproteinases, and tissue inhibitor of metalloproteinases, in uncontrolled proliferation and migration of smooth muscle cells towards the lumen, and invasion of the graft conduit. We identified potential target sites that could be useful in preventing and (or) reversing unwanted consequences following coronary artery bypass graft using saphenous vein.

Original languageEnglish
Pages (from-to)531-545
Number of pages15
JournalCanadian Journal of Physiology and Pharmacology
Volume92
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Tunica Intima
Saphenous Vein
Coronary Artery Bypass
Hyperplasia
Transplants
Mammary Arteries
Smooth Muscle Myocytes
Phosphoric Monoester Hydrolases
Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Veins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)
  • Pharmacology
  • Medicine(all)

Cite this

Coronary artery bypass graft : Why is the saphenous vein prone to intimal hyperplasia?1. / Sur, Swastika; Sugimoto, Jeffrey T.; Agrawal, Devendra K.

In: Canadian Journal of Physiology and Pharmacology, Vol. 92, No. 7, 2014, p. 531-545.

Research output: Contribution to journalArticle

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