Coronary Artery Disease Prognosis and C-Reactive Protein Levels Improve in Proportion to Percent Lowering of Low-Density Lipoprotein

James H. O'Keefe, Loren Cordain, Philip G. Jones, Hussam Abuissa

Research output: Contribution to journalComment/debate

14 Scopus citations


This editorial outlines the data supporting aggressive lipid goals and options for treating low-density lipoprotein (LDL) cholesterol to a range of approximately 30 to 70 mg/dl. The physiologically normal cholesterol range is approximately 30 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and virtually all wild mammals. Randomized statin trials in patients with recent acute coronary syndromes and stable coronary artery disease have demonstrated that cardiovascular events are reduced and cardiovascular survival optimized when LDL cholesterol is reduced to

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalAmerican Journal of Cardiology
Issue number1
StatePublished - Jul 1 2006
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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